胰腺癌仍然是一个重大的健康问题，治疗选择有限。肿瘤基质是由不同细胞和蛋白质组成的复杂环境，在肿瘤生长和化疗耐药中发挥着至关重要的作用。靶向由多种非肿瘤细胞（如成纤维细胞、细胞外基质（ECM）、免疫细胞以及前血管细胞）组成的肿瘤基质对于重塑实体癌（如胰腺癌）是令人鼓舞的。重塑胰腺肿瘤的基质可以作为减少化疗/免疫治疗耐药性的策略。多项研究表明，植物中的植物化学物质可以影响肿瘤环境并具有抗癌特性。通过靶向基质激活的关键途径，植物化学物质可能会破坏肿瘤和基质之间的通讯，并使肿瘤细胞对不同的治疗更加敏感。此外，植物化学物质具有免疫调节和抗血管生成的特性，所有这些都有助于它们治疗胰腺癌的潜力。这篇综述将详细介绍植物化学物质如何影响肿瘤基质及其对胰腺肿瘤生长、扩散和治疗反应的影响。它还将探索将植物化学物质与化疗、免疫疗法和放射等其他治疗方案相结合的潜力。© 2024。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下公司）的独家许可。

Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different cells and proteins, plays a crucial role in tumor growth and chemoresistance. Targeting tumor stroma, consisting of diverse non-tumor cells such as fibroblasts, extracellular matrix (ECM), immune cells, and also pre-vascular cells is encouraging for remodeling solid cancers, such as pancreatic cancer. Remodeling the stroma of pancreas tumors can be suggested as a strategy for reducing resistance to chemo/immunotherapy. Several studies have shown that phytochemicals from plants can affect the tumor environment and have anti-cancer properties. By targeting key pathways involved in stromal activation, phytochemicals may disrupt communication between the tumor and stroma and make tumor cells more sensitive to different treatments. Additionally, phytochemicals have immunomodulatory and anti-angiogenic properties, all of which contribute to their potential in treating pancreatic cancer. This review will provide a detailed look at how phytochemicals impact the tumor stroma and their effects on pancreatic tumor growth, spread, and response to treatment. It will also explore the potential of combining phytochemicals with other treatment options like chemotherapy, immunotherapy, and radiation.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.