研究动态
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减少癌症幸存者心血管结局的种族和民族差异。

Reducing racial and ethnic disparities in cardiovascular outcomes among cancer survivors.

发表日期:2024 Jul 13
作者: Min Choon Tan, Nickolas Stabellini, Jia Yi Tan, Jia Yean Thong, Catherine Hedrick, Justin Xavier Moore, Jennifer Cullen, Anika Hines, Arnethea Sutton, Vanessa Sheppard, Neeraj Agarwal, Avirup Guha
来源: Epigenetics & Chromatin

摘要:

分析癌症幸存者心血管结局中种族/民族差异的现有证据,确定因素并提出解决健康不平等问题的措施。现有文献表明,在诊断出原发性癌症和第二原发性癌症后,黑人人口的心血管结局更差,其中心脏毒性事件的发生率明显较高,特别是在乳腺癌幸存者中。造成这些差异的社会经济因素包括不利的健康社会决定因素、保险覆盖范围不足以及医疗保健系统内的结构性种族主义。此外,促炎症表观遗传修饰被认为是一个促成遗传变异的因素。解决这些差异需要采取多视角的方法,包括努力解决医疗保健系统内的种族差异和健康的社会决定因素,完善医疗保健政策和准入,并将历史上受到污名化的种族群体纳入临床研究。癌症幸存者心血管结局方面持续存在种族和民族差异,这是由多因素驱动的,主要与健康的社会决定因素有关。解决这些医疗保健不平等问题势在必行,必须及时采取措施,有效缩小现有差距。© 2024。作者获得 Springer Science Business Media, LLC(Springer Nature 旗下子公司)的独家许可。
Analyze current evidence on racial/ethnic disparities in cardiovascular outcomes among cancer survivors, identifying factors and proposing measures to address health inequities.Existing literature indicates that the Black population experiences worse cardiovascular outcomes following the diagnosis of both initial primary cancer and second primary cancer, with a notably higher prevalence of cardio-toxic events, particularly among breast cancer survivors. Contributing socioeconomic factors to these disparities include unfavorable social determinants of health, inadequate insurance coverage, and structural racism within the healthcare system. Additionally, proinflammatory epigenetic modification is hypothesized to be a contributing genetic variation factor. Addressing these disparities requires a multiperspective approach, encompassing efforts to address racial disparities and social determinants of health within the healthcare system, refine healthcare policies and access, and integrate historically stigmatized racial groups into clinical research. Racial and ethnic disparities persist in cardiovascular outcomes among cancer survivors, driven by multifactorial causes, predominantly associated with social determinants of health. Addressing these healthcare inequities is imperative, and timely efforts must be implemented to narrow the existing gap effectively.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.