慢性低度炎症是肥胖的一个常见特征，在其并发症的进展中起着至关重要的作用。维生素 D (VitD) 在调节免疫反应和调节炎症方面发挥着重要作用。因此，本系统综述和荟萃分析旨在评估单独补充 VitD 对无合并症且 VitD 缺乏的超重和肥胖个体主要炎症标志物的影响。我们假设补充后血清 VitD 浓度的增加会显着降低炎症标志物的浓度。该检索是在 Medline/PubMed、SCOPUS、EMBASE 和 Web of Science 上进行的。最终分析中纳入了 11 项随机安慰剂对照研究，共有 504 名参与者，每日（1000-7000 国际单位）或推注（100,000-200,000 国际单位）剂量的 VitD 持续 2 至 26 周。补充 VitD 不会影响 C 反应蛋白（平均差 [MD]：0.01；95% 置信区间 [CI] -0.37, 0.39；P = .97）、白细胞介素 6（MD：-0.34；95% CI - 1.09，0.42；P = .38）和肿瘤坏死因子浓度（MD：-0.02；95% CI -0.23，0.19；P = .85）。在考虑血清 VitD 浓度显着增加的研究的分析中，补充 VitD 也不会影响 C 反应蛋白（MD：-0.17；95% CI -0.88，0.54；P = .64）、白细胞介素 6（MD ：-0.47；95% CI -1.31，0.37；P = .27）和肿瘤坏死因子浓度（MD：0.01；95% CI -1.34，1.37；P = .98）。这项荟萃分析表明，补充 VitD 不会显着改变超重和肥胖个体的炎症标志物。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Chronic low-grade inflammation is a common feature of obesity and plays a crucial role in the progression of its complications. Vitamin D (VitD) plays an important role in modulating the immune response and regulating inflammation. Thus, this systematic review and meta-analysis aimed to evaluate the effects of isolated VitD supplementation on main inflammatory markers in overweight and obese individuals with no comorbidities and with VitD deficiency. We hypothesized that the increase in serum VitD concentrations after supplementation would significantly reduce the concentrations of inflammatory markers. The search was conducted in Medline/PubMed, SCOPUS, EMBASE, and Web of Science. Eleven randomized placebo-controlled studies were included in the final analysis, with a total of 504 participants and daily (1000-7000 international units) or bolus (100,000-200,000 international units) doses of VitD lasting from 2 to 26 weeks. The VitD supplementation did not influence C-reactive protein (mean difference [MD]: 0.01; 95% confidence interval [CI] -0.37, 0.39; P = .97), interleukin-6 (MD: -0.34; 95% CI -1.09, 0.42; P = .38), and tumor necrosis factor concentrations (MD: -0.02; 95% CI -0.23, 0.19; P = .85). In the analysis considering the studies with a significant increase in serum VitD concentrations, VitD supplementation also did not influence C-reactive protein (MD: -0.17; 95% CI -0.88, 0.54; P = .64), interleukin-6 (MD: -0.47; 95% CI -1.31, 0.37; P = .27), and tumor necrosis factor concentrations (MD: 0.01; 95% CI -1.34, 1.37; P = .98). This meta-analysis suggests that VitD supplementation does not significantly alter inflammatory markers in overweight and obese individuals.Copyright © 2024 Elsevier Inc. All rights reserved.