旨在评估与常规护理相比，综合老年评估 (CGA) 指导的护理是否可以改善患有癌症的老年人的健康相关生活质量 (HRQL)。通过生物医学数据库确定了相关随机对照试验 (RCT)。使用 DerSimonian-Laird 模型的荟萃分析总结了不同时间点 HRQL 评分相对于基线的平均变化的差异，并通过 GRADE 工具评估了证据确定性。通过广义估计方程的 Logistic 回归分析了 HRQL 改善的预测因子。不能排除 3 个月时 CGA 指导护理对整体 HRQL 评分的潜在改善（Cohen's d 0.27，95% CI -0.03 至 0.58，中等确定性）。较大的随机对照试验或在开始抗癌治疗之前强制进行 CGA 的试验是 HRQL 改善的预测因素。CGA 指导的护理对 HRQL 的影响是可变的。较大的随机对照试验和强制治疗前 CGA 的试验往往会报告 HRQL 的改善。版权所有 © 2024 Elsevier B.V. 保留所有权利。

To evaluate if comprehensive geriatric assessment (CGA)-guided care improves health-related quality of life (HRQL) in older adults with cancer compared to usual care.Relevant randomized controlled trials (RCTs) were identified through biomedical databases. Meta-analyses using DerSimonian-Laird model summarized the difference in the mean change of HRQL scores from baseline across various time points, with evidence certainty assessed by the GRADE tool. Logistic regression via generalized estimating equations analyzed predictors of HRQL improvement.Potential improvement in the global HRQL score by CGA-guided care at 3 months (Cohen's d 0.27, 95% CI -0.03 to 0.58, moderate certainty), could not be excluded. Larger RCTs or those mandating CGA before initiating anti-cancer treatment were predictors of improved HRQL.The effects of CGA-guided care on HRQL were variable. Larger RCTs and those mandating pre-treatment CGA tended to report improved HRQL.Copyright © 2024 Elsevier B.V. All rights reserved.