主动脉肉瘤骨转移患者。
Aortic Sarcoma Patients With Bone Metastasis.
发表日期:2024 Jul 11
作者:
Tam Mai Thi Minh, Chung Tran Nam, Huu Nguyen Cong, Thanh Le Ngoc, Christian Roux, Binh Tran Quang, Mai Hang Nguyen
来源:
Bone & Joint Journal
摘要:
主动脉肉瘤骨转移包括溶骨性和非溶骨性病变。本研究旨在综述主动脉肉瘤骨转移的临床症状、部位和诊断方法,并比较主动脉肉瘤患者的溶骨性和非溶骨性转移。在 1972 年至 2022 年出版的 PubMed 和科学期刊中进行了系统检索。包括以英文和法文发表的主动脉肉瘤骨转移的报告。采用卡方检验或Fisher精确检验分析溶解性骨转移和硬化性骨转移的患者特征。 29例骨破坏患者中,10例(34.5%)出现腰痛、跛行症状,9例(31例)出现腰痛、跛行症状。 %), 分别。腿部和手臂急性缺血7例(24.1%)。合并高血压4例(13.8%),胸痛、腹痛、上腹痛5例(17.2%)。椎骨、骨盆、股骨转移分别为14例(48.3%)、12例(41.4%)和11例(37.9%)。 16/29 (55.2%) 病例在诊断时发现溶骨性病变。 27例主动脉肉瘤伴硬化性骨转移患者中,有高血压症状10例(37.0%),有背痛7例(25.9%),有胸痛或腹痛5例(18.5%)。下肢急性缺血6例(22.2%)。椎骨、骨、骨盆和股骨转移分别为10例(37.0%)、9例(33.3%)、7例(25.9%)和6例(22.2%)。跛行征象和 X 射线检测骨破坏的方法分别是主动脉肉瘤溶骨性转移和非溶骨性转移之间的差异 (p=0,019; p=0,001)。背痛是主动脉肉瘤伴骨的常见症状转移。间歇性跛行的征象是主动脉肉瘤溶骨性和非溶骨性转移的区别。骨质破坏发生在所有骨骼中,但主要发生在椎骨、骨盆、股骨。检测骨破坏的方法主要采用X线或CT。骨质破坏是检测主动脉肉瘤的重要标志。硬化性骨转移主要发生在椎骨、骨盆、骨和股骨。基于 MRI、PET/CT 和尸检的硬化骨转移检测。版权所有 © 2024。由 Elsevier Inc. 出版。
Metastases to the bone of aortic sarcoma include osteolytic and non-osteolytic lesions. This study aims to review the clinical symptoms, the sites and diagnostic methods of bone metastases and to compare the osteolytic and non-osteolytic metastases of patients with aortic sarcoma.A systematic search was conducted in PubMed and scientific journals published from 1972 to 2022. Database included reports of aortic sarcomas with bone metastasis published in english and in french. Characteristics of patients were analyzed with Chi-square test or Fisher's exact test between lytic and sclerotic bone metastases.In 29 patients with bone destruction, the symptoms of low back pain and claudication were observed in 10 (34.5%), and 9 cases (31%), respectively. Acute ischemia of the legs and arms accounted for 7 cases (24.1%). There were 4 cases with hypertension (13.8%) and 5 cases with chest pain or abdominal pain or epigastric pain (17.2%). Metastases to the vertebrae, pelvis, femur were observed in 14 (48.3%), 12 (41.4%) and 11 cases (37.9%), respectively. Osteolytic lesions were detected at the time of diagnosis in 16/29 (55.2%) cases. In 27 aortic sarcoma patients with sclerotic bone metastases, symptoms of hypertension were observed in 10 (37.0%), of back pain in 7 (25.9 %), of chest pain or abdominal pain in 5 cases (18.5%). Acute ischemia of the leg occurred in 6 cases (22.2%). Metastases to the vertebrae, bone, pelvis, and femur were observed in 10 (37.0%), 9 (33.3%), 7 (25.9%), and 6 cases (22.2%), respectively. The sign of claudication and methods for detected bone destruction by X-rays were the difference between osteolytic and non-osteolytic metastases of aortic sarcoma (p=0,019; p=0,001), respectively.Back pain is a common symptom of aortic sarcoma with bone metastasis. The sign of intermittent claudication is the difference between osteolytic and non-osteolytic metastases of aortic sarcoma. Bone destruction occurred in all bones, but mainly in vertebrae, pelvis, femur. Methods for detection of bone destruction mainly by X-rays or CT. Bone destruction was an important sign to detect aortic sarcoma. Sclerotic bone metastases occurred mainly in vertebrae, pelvis, bone and femur. The detection of sclerotic bone metastases based on MRI, PET/CT and autopsy.Copyright © 2024. Published by Elsevier Inc.