结直肠癌是全世界最常见的癌症类型之一，可导致严重伤害和死亡。尽管多糖被广泛认为具有抗肿瘤活性，但关于大麦多糖（BP）1在结直肠癌中的作用的研究很少。我们的研究结果表明，BP（300mg/kg）对结直肠癌具有显着的抑制作用，并且这种作用是通过两个途径实现的。首先，BP可以直接促进5-(4-羟基苯基)-5-苯基咪唑烷-2,4-二酮和2,3-双(4-羟基苯基)丙腈等保护性代谢物的分泌，从而抑制ERK等癌症通路， PI3K、WNT、JAK-STAT、钙和细胞周期癌症途径可减轻炎症。其次，BP还能丰富肠道有益菌，如Colidextribacter、Bilophila和UCG-003，改善肠道屏障，促进有益代谢产物如5,8-Epoxy-5,8-diHydro-3-Hydroxy-8'的产生。 -apo-b,y-胡萝卜素和L-谷氨酸，从而抑制ERK、PI3K、核受体、细胞周期、细胞凋亡和TGF-β等癌症途径。总之，我们的研究结果首次表明 BP 可以通过两种相对独立的途径缓解结直肠癌：直接作用和通过肠道微生物群对结肠肿瘤细胞和微生物群的间接作用。版权所有 © 2024。由 Elsevier B.V. 出版。

Colorectal cancer is one of the most common types of cancer worldwide that can lead to serious injury and death. Although polysaccharides are widely recognized as having antitumor activity, there has been little research on the role of barley polysaccharides (BP)1 in colorectal cancer. The results of our research suggest that BP (300 mg/kg) had a significant inhibitory effect on colorectal cancer, and this effect was achieved through two pathways. First, BP can directly promote the secretion of protective metabolites like 5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione and 2,3-Bis(4-hydroxyphenyl)propionitrile thereby inhibiting the cancer pathways such as ERK, PI3K, WNT, JAK-STAT, Calcium, and Cell cycle cancer pathways to alleviate inflammation. Second, BP also can enrich beneficial intestinal bacteria such as Colidextribacter, Bilophila, and UCG-003 improve the intestinal barrier, promote the production of beneficial metabolites such as 5,8-Epoxy-5,8-dihydro-3-hydroxy-8'-apo-b,y-carotenal and L-Glutamic acid, and thus inhibit cancer pathways such as ERK, PI3K, Nuclear receptor, Cell cycle, Apoptosis and TGF-β. In conclusion, our findings suggest for the first time that BP can alleviate colorectal cancer by two relatively independent pathways: direct action and indirect action via the gut microbiota on both colon tumor cells and microbiota.Copyright © 2024. Published by Elsevier B.V.