了解子宫内膜癌女性卵巢受累发生率和危险因素可能有助于决定保留卵巢。我们的回顾性研究纳入了 2005 年 1 月至 2021 年 11 月期间接受初次手术的所有连续完全手术分期子宫内膜癌患者，评估了卵巢转移的发生率，其作为复发和死亡的预后因素的作用，并评估了附件受累的预测因子。国际妇产科联合会 (FIGO) 2009 年 IIIA 期子宫内膜癌女性占人口的 2.3%（1535 名患者中的 36 名），23（ 63.9%）具有子宫内膜样组织学特征，中位年龄为 57.0 岁（范围 47.7-66.7）。较高的体重指数、绝经后状态、子宫内膜样组织型和β-连环蛋白表达与较低的附件受累风险相关。相反，dMMR表型、p53表达、子宫肌层浸润>50%、淋巴管间隙侵犯和宫颈间质侵犯是附件受累风险增加的独立预测因子。共有145例（9.5%）患者有附件受累，发病率为0.27/100人·天。 FigO (2009) IIIA 期的总生存率为 88.9%。我们的研究表明，对于年轻的低风险子宫内膜癌患者（G1 和 G2 肿瘤、无淋巴管间隙侵犯、无宫颈受累和子宫肌层侵犯）可考虑保留卵巢<50%），对较高的体重指数和高 β-连环蛋白表达具有有利的预测作用。© IGCS 和 ESGO 2024。不得商业重复使用。请参阅权利和权限。英国医学杂志出版。

Understanding ovarian involvement incidence and risk factors in women with endometrial cancer may inform the decision of ovary preservation.Our retrospective study included all consecutive fully surgically staged patients with endometrial cancer who underwent primary surgery between January 2005 and November 2021, assessing the incidence of ovarian metastasis, its role as a prognostic factor for recurrence and death, and evaluated predictors of adnexal involvement.Women with International Federation of Gynecology and Obstetrics (FIGO) 2009 IIIA endometrial cancer comprised 2.3% of the population (36 of 1535 included patients), 23 (63.9%) with endometrioid histology, and a median age of 57.0 years (range 47.7-66.7). A higher body mass index, post-menopausal status, endometrioid histotype, and β-catenin expression were associated with a lower risk of adnexal involvement. Conversely, dMMR phenotype, p53 expression, myometrial infiltration >50%, lymphovascular space invasion, and cervical stromal invasion were independent predictors of an increased risk of adnexal involvement. A total of 145 (9.5%) patients had adnexal involvement, with an incidence rate of 0.27/100 person-days. Overall survival for FIGO (2009) stage IIIA was 88.9%.Our study showed that ovarian preservation may be considered for younger patients with low-risk endometrial cancer (G1 and G2 tumors, absence of lymphovascular space invasion, no cervical involvement, and myometrial invasion <50%), adding a favorable predictive role to higher body mass index and high β-catenin expression.© IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.