内分泌干​​扰化学物质 (EDC) 是干扰内分泌系统正常功能的天然或人造化合物。越来越多的证据表明，接触 EDC 会对生殖、代谢紊乱、神经系统改变产生深远的不利影响，并增加患激素依赖性癌症的风险。干细胞 (SC) 是这些病理过程不可或缺的一部分，因此了解 EDC 如何影响 SC 功能至关重要。本综述审查了有关不同类型 EDC 及其对各种类型 SC 的影响的文献，包括胚胎、成人和癌症 SC。还评估了 EDC 影响 SC 表型的可能分子机制。最后，讨论了这些影响对人类健康可能产生的影响。现有文献表明，EDC 可以通过多种方式影响 SC 的生物学，包括改变激素途径、DNA 损伤、表观遗传变化、活性氧的产生和基因表达模式的改变。这些破坏可能会导致成年后的各种细胞命运和疾病，包括内分泌失调、肥胖、不孕、生殖异常和癌症的风险增加。因此，该审查强调了提高人们对 EDC 对人类健康的复杂影响的更广泛认识的重要性。版权所有 © 2023。由 Elsevier B.V. 出版。

Endocrine-disrupting chemicals (EDCs) are compounds, either natural or man-made, that interfere with the normal functioning of the endocrine system. There is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction, metabolic disorders, neurological alterations, and increased risk of hormone-dependent cancer. Stem cells (SCs) are integral to these pathological processes, and it is therefore crucial to understand how EDCs may influence SC functionality. This review examines the literature on different types of EDCs and their effects on various types of SCs, including embryonic, adult, and cancer SCs. Possible molecular mechanisms through which EDCs may influence the phenotype of SCs are also evaluated. Finally, the possible implications of these effects on human health are discussed. The available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways, including by altering hormonal pathways, DNA damage, epigenetic changes, reactive oxygen species production and alterations in the gene expression patterns. These disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders, obesity, infertility, reproductive abnormalities, and cancer. Therefore, the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.Copyright © 2023. Published by Elsevier B.V.