原发性胃腺鳞癌（PGASC）是一种罕见的胃癌类型，研究有限，临床病理特征知之甚少。本研究调查了 PGASC 的临床病理特征和结果。来自华中科技大学同济医学院附属协和医院以及已发表文献的 PGASC 患者纳入本研究。使用 Kaplan-Meier 方法生成生存曲线，并通过 Cox 比例风险回归模型确定预后因素。本研究确定了 76 例符合条件的 PGASC 病例，其中 45 例来自已发表的文献，31 例来自我们中心。最常见的症状是腹痛和吞咽困难，中位年龄为 62 岁（范围：29-84 岁）。原发灶主要位于近端胃，肿瘤中位大小为 6.5 cm（范围：1.5-16.0 cm）。分别有 12 名（16.7%）、43 名（59.7%）和 17 名（23.6%）患者检测到肿瘤分期 II、III 和 IV。大多数肿瘤的鳞状细胞癌（SCC）成分和腺癌（AC）成分均分化不良。中位生存时间为 17 个月（范围：2-122 个月）。 1年、3年和5年总生存率(OS)分别为60.7%、31.1%和24.1%。多变量分析显示，OS 可通过 SCC 成分的比例、AC 成分的分化和肿瘤分期独立预测。 PGASC 是一种罕见疾病，预后较差。高比例的 SCC 成分、低分化 AC 成分和晚期肿瘤与 PGASC 患者较差的生存率相关。辅助治疗并未延长生存时间。© 2024。作者。

Primary gastric adenosquamous carcinoma (PGASC) is a rare type of gastric cancer with limited research and poorly understood clinicopathological features. This study investigated the clinicopathological features and outcomes of PGASC. Patients with PGASC from Union Hospital, Tongji Medical College, Huazhong University of Science and Technology and from the published literature were enrolled in this study. Survival curves were generated using the Kaplan-Meier method, and prognostic factors were identified through Cox proportional hazards regression models. This study identified 76 eligible cases of PGASC, with 45 cases from published literature and 31 from our center. The most prevalent symptoms were abdominal pain and dysphagia, with a median age of 62 years (range: 29-84 years). The primary lesions were predominantly in the proximal stomach, with a median tumor size of 6.5 cm (range: 1.5-16.0 cm). Tumor stages II, III, and IV were detected in 12 (16.7%), 43 (59.7%), and 17 (23.6%) patients, respectively. Most tumors were poorly differentiated in both the squamous cell carcinoma (SCC) component and adenocarcinoma (AC) component. The median survival time was 17 months (range: 2-122 months). The 1, 3, and 5-year overall survival (OS) was 60.7%, 31.1%, and 24.1%, respectively. Multivariate analysis revealed that OS was independently predicted by the proportion of SCC component, differentiation of AC component, and tumor stage. PGASC is a rare disease with a poor prognosis. A high proportion of SCC components, low differentiated AC components, and advanced tumor were associated with worse survival in patients with PGASC. Adjuvant therapy did not improve survival time.© 2024. The Author(s).