手术时间 (TTS) 越长，乳腺癌患者的生存期越差。这种关联是否鼓励了更及时的护理服务仍不得而知。国家癌症数据库用于识别 2006 年至 2019 年间诊断为临床 0-III 期乳腺癌的 18 岁以上患者，这些患者的首选治疗方式是手术。 对趋势进行逐线性测试，评估整个时间间隔内的 TTS 中值。调整后的线性回归模型用于检查患者亚组的 TTS 趋势。总体而言，1,435,584 名患者符合纳入标准。中位年龄为 63 岁（四分位距 [IQR] 53-72），84.3% 的患者为白人，91.1% 为非西班牙裔，99.2% 为女性。 2006 年的中位 TTS 为 26 天 (IQR 16-39)，而 2019 年为 39 天 (IQR 27-56) [p < 0.001]。在多变量线性回归模型中，TTS 显着增加，每年增加 0.83 天（95% 置信区间 0.82-0.85；p < 0.001）。 根据手术类型、重建、患者种族、医院类型和疾病阶段进行亚组分析，观察到 TTS 一致、显着增加。黑人种族、西班牙裔以及拥有医疗补助或没有保险与延长的 TTS 显着相关，乳房切除术和重建手术也是如此。尽管有证据表明较长的 TTS 与乳腺癌患者的较差预后相关，但 TTS 一直在稳步增加，这可能对边缘化患者尤其不利。需要进一步研究以确保为所有患者提供及时护理。© 2024。作者。

Longer time to surgery (TTS) is associated with worse survival in patients with breast cancer. Whether this association has encouraged more prompt care delivery remains unknown.The National Cancer Database was used to identify patients ≥18 years of age diagnosed with clinical stage 0-III breast cancer between 2006 and 2019 for whom surgery was the first mode of treatment. A linear-by-linear test for trend assessed median TTS across the interval. Adjusted linear regression modeling was used to examine TTS trends across patient subgroups.Overall, 1,435,584 patients met the inclusion criteria. The median age was 63 years (interquartile range [IQR] 53-72), 84.3% of patients were White, 91.1% were non-Hispanic, and 99.2% were female. The median TTS in 2006 was 26 days (IQR 16-39) versus 39 days in 2019 (IQR 27-56) [p < 0.001]. In a multivariable linear regression model, TTS increased significantly, with an annual increase of 0.83 days (95% confidence interval 0.82-0.85; p < 0.001). A consistent, significant increase in TTS was observed on subgroup analyses by surgery type, reconstruction, patient race, hospital type, and disease stage. Black race, Hispanic ethnicity, and having either Medicaid or being uninsured were significantly associated with prolonged TTS, as were mastectomy and reconstructive surgery.Despite evidence that longer TTS is associated with poorer outcomes in patients with breast cancer, TTS has steadily increased, which may be particularly detrimental to marginalized patients. Further studies are needed to ensure the delivery of timely care to all patients.© 2024. The Author(s).