细胞焦亡是程序性细胞死亡的一种炎症形式，与坏死和细胞凋亡不同。细胞焦亡主要由 Gasdermin 蛋白家族（GSDMA-E 和 PVJK）介导，当蛋白水解裂解激活时，它们会在质膜上形成孔，导致细胞死亡。虽然过去对焦亡的大部分研究都集中在其在癌症、代谢紊乱和传染病中的作用，但最近的实验和观察研究已开始表明焦亡与过敏性疾病有关。这些研究表明，gasdermin 介导的细胞焦亡会导致过敏性疾病的发生，并可能为治疗提供新的靶点。在这里，我们回顾了目前对细胞焦亡的理解，重点介绍了 Gasdermin 作为焦亡执行者和过敏性疾病潜在介质的作用。我们重点介绍在 Gasdermin 的生化作用与过敏性疾病发作之间建立机制联系的新发现。此外，我们还讨论了细胞焦亡和gasdermins如何导致上皮屏障功能障碍，上皮屏障功能障碍被认为是引发各种过敏性疾病进展的关键因素。© 2024 欧洲过敏和临床免疫学学会和 John Wiley

Pyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA-E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death. While much of the past research on pyroptosis has focused on its role in cancer, metabolic disorders, and infectious diseases, recent experimental and observational studies have begun to implicate pyroptosis in allergic diseases. These studies suggest that gasdermin-mediated pyroptosis contributes to the development of allergic conditions and could offer novel targets for therapy. Here, we review our current understanding of pyroptosis with an emphasis on the role of gasdermins as executioners of pyroptosis and potential mediators to allergic disease. We highlight new discoveries that establish a mechanistic link between the biochemical actions of gasdermins and the onset of allergic diseases. Additionally, we discuss how pyroptosis and gasdermins might contribute to the dysfunction of epithelial barrier, a key factor believed to initiate the progression of various allergic diseases.© 2024 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.