凋亡，加油和过敏性疾病
Pyroptosis, gasdermins and allergic diseases
影响因子:12.00000
分区:医学1区 Top / 过敏1区 免疫学1区
发表日期:2024 Sep
作者:
Ronald Allan Panganiban, Kari C Nadeau, Quan Lu
摘要
凋亡是一种编程细胞死亡的炎症形式，与坏死和凋亡不同。凋亡主要是由蛋白质的加油蛋白家族（GSDMA-E和PVJK）介导的，当通过蛋白水解裂解激活时，它会在质膜中形成孔，从而导致细胞死亡。尽管过去的大部分关于凋亡的研究都集中在其在癌症，代谢性疾病和传染病中的作用，但最近的实验和观察性研究开始牵涉到过敏性疾病中的热吞作用。这些研究表明，加油动物介导的凋亡有助于过敏性疾病的发展，并可以为治疗提供新的靶标。在这里，我们回顾了我们目前对凋亡的理解，重点是加油动物作为动力杀死者的作用和对过敏性疾病的潜在介体的作用。我们重点介绍了新发现，这些发现在加油动物的生化作用与过敏性疾病发作之间建立了机械联系。此外，我们讨论了凋亡和毒药如何导致上皮屏障功能障碍，这是据信启动各种过敏性疾病进展的关键因素。
Abstract
Pyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA-E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death. While much of the past research on pyroptosis has focused on its role in cancer, metabolic disorders, and infectious diseases, recent experimental and observational studies have begun to implicate pyroptosis in allergic diseases. These studies suggest that gasdermin-mediated pyroptosis contributes to the development of allergic conditions and could offer novel targets for therapy. Here, we review our current understanding of pyroptosis with an emphasis on the role of gasdermins as executioners of pyroptosis and potential mediators to allergic disease. We highlight new discoveries that establish a mechanistic link between the biochemical actions of gasdermins and the onset of allergic diseases. Additionally, we discuss how pyroptosis and gasdermins might contribute to the dysfunction of epithelial barrier, a key factor believed to initiate the progression of various allergic diseases.