骨骼是各种晚期癌症（包括肺癌、乳腺癌、前列腺癌、结直肠癌和黑色素瘤）中常见的受转移影响的器官。一旦患者被诊断患有骨转移，由于发病范围广泛且治疗难度不断增加，患者的生活质量和总体生存率显着降低。许多研究表明骨转移与骨微环境尤其是骨免疫微环境密切相关。然而，骨微环境中各种免疫细胞对骨转移的影响仍不清楚。在这里，我们描述了骨转移过程中各种免疫细胞的变化，并讨论了它们的相关机制。成骨细胞、脂肪细胞和其他与骨转移密切相关的非免疫细胞也包括在内。该综述还总结了现有的治疗方法和潜在的治疗靶点，并为未来癌症骨转移的研究提供了见解。© 2024 作者。约翰·威利出版的《癌症通讯》

Bone is a common organ affected by metastasis in various advanced cancers, including lung, breast, prostate, colorectal, and melanoma. Once a patient is diagnosed with bone metastasis, the patient's quality of life and overall survival are significantly reduced owing to a wide range of morbidities and the increasing difficulty of treatment. Many studies have shown that bone metastasis is closely related to bone microenvironment, especially bone immune microenvironment. However, the effects of various immune cells in the bone microenvironment on bone metastasis remain unclear. Here, we described the changes in various immune cells during bone metastasis and discussed their related mechanisms. Osteoblasts, adipocytes, and other non-immune cells closely related to bone metastasis were also included. This review also summarized the existing treatment methods and potential therapeutic targets, and provided insights for future studies of cancer bone metastasis.© 2024 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd on behalf of Sun Yat‐sen University Cancer Center.