异位甲状旁腺癌（EPC）是一种罕见的临床实体，具有多种诊断缺陷，使得手术治疗具有挑战性。我们评估了 EPC 的临床病理学谱和结果。在这项回顾性队列研究中，从三级转诊中心治疗的 133 名 PC 患者中鉴定出 24 例 EPC。分析临床病理结果与部位的关系。EPCs的部位以甲状腺内为主（62.5%），其次为纵隔（16.7%）、咽后间隙（8.3%）、颈动脉鞘（8.3%）、上动脉（4.2%）。脖子。与其他异位部位的患者相比，甲状腺内EPC患者的血清钙含量较高（p = 0.020），血管侵犯率较高（p = 0.040），非R0初次切除发生率略高（p = 0.092）。与其他 PC 患者相比，甲状腺内 EPC 患者的上呼吸消化道 (UAT) 侵袭率也较高 (p = 0.070)，远处转移风险也较高 (p = 0.037)。甲状腺内 EPC 患者术后 5 年无病生存率略有下降，为 41.5%，而其他异位部位的患者为 77.8% (p = 0.143)，其他 PC 患者为 59.7% (log-rank = 3.194)。 ；p = 0.074），但没有统计学意义。与其他 PC 相比，甲状腺内 EPC 可能会导致更加生化和侵入性的 PC 图像。在此类病例的术前诊断和处理中应特别谨慎。© 2024。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下公司）的独家许可。

Ectopic parathyroid carcinoma (EPC) is a rare clinical entity with multiple diagnostic pitfalls, making surgical cures challenging. We assessed the clinicopathological spectrum and outcome of EPCs.In this retrospective cohort study, 24 EPCs were identified from 133 PC patients treated at a tertiary referral center. The relationship between clinicopathological findings and locations was analyzed.The locations of EPCs were predominantly intrathyroidal (62.5%), followed by 16.7% in the mediastinum, 8.3% in the retropharyngeal space, 8.3% in the carotid sheath, and 4.2% in the upper neck. Intrathyroidal EPC patients experienced higher serum calcium (p = 0.020), a higher rate of vascular invasion (p = 0.040), and a slightly higher incidence of non-R0 initial resection (p = 0.092) than those in other ectopic locations. Intrathyroidal EPC patients also suffered a trend of higher upper aerodigestive tract (UAT) invasion rate (p = 0.070) and higher risks of distant metastasis (p = 0.037) than the other PC patients. The 5-year disease-free survival rate after surgery was slightly compromised at 41.5% in intrathyroidal EPC patients compared with 77.8% among those in other ectopic locations (p = 0.143) and 59.7% among the other PC patients (log-rank = 3.194; p = 0.074), though without statistical significance.Intrathyroidal EPC might cause a more biochemically and invasively distinct PC picture compared with other PCs. Special caution should be exercised in the preoperative diagnosis and management of such cases.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.