Trametes Robiniophila Murr，俗称槐耳，在中国的民族药理学研究中已有广泛记载。槐耳在我国临床应用已有1000多年的悠久历史。传统的临床应用记录表明槐耳在治疗各种癌症和增强肿瘤患者自身免疫方面具有广泛的用途。本研究对槐耳的传统用途、植物化学成分、药理活性、抗肿瘤机制和潜在应用进行了全面的回顾本研究采用关键词“Trametes Robiniophila Murr”和“槐耳”从PubMed、Web of Science、Springer、Science等数据库中检索槐耳的相关信息。 Direct、ACS、Wiley、CNKI、百度学术、谷歌学术、古本草等。槐耳为中药，在临床治疗多种肿瘤中显示出显着疗效。槐耳的主要生物活性成分由真菌衍生的化合物组成，包括多糖、蛋白质、酮、生物碱和矿物质。研究结果表明，槐耳可有效抑制癌细胞增殖、诱导癌细胞凋亡、抑制肿瘤转移、调节肿瘤干细胞和免疫功能，是一种可靠的辅助治疗药物。因此，与传统抗癌疗法结合使用时，它可以发挥有效的抗肿瘤作用。对传统用途、植物化学成分和药理活性的分析表明，槐耳作为具有多种药理作用的药用植物具有巨大的潜力。由于其众多优势，槐尔在肿瘤预防和治疗领域具有广阔的应用前景，可提高癌症患者的生存时间和生活质量。版权所有 © 2024。由 Elsevier B.V. 出版。

Trametes Robiniophila Murr, commonly known as Huaier, has been extensively documented in ethnopharmacology research in China. Huaier has a long history of clinical usage spanning over 1000 years in China. Traditional clinical application records demonstrate the wide utilization of Huaier for treating various cancers and enhancing the autoimmunity of tumor patients.The present study provides a comprehensive review of the traditional uses, phytochemical constituents, pharmacological activities, anti-tumor mechanism, and potential applications of Huaier, thereby offering valuable insights for the further development and utilization of this natural product.This study employed the keywords "Trametes Robiniophila Murr" and "Huaier" to retrieve relevant information on Huaier from various databases, including PubMed, Web of Science, Springer, Science Direct, ACS, Wiley, CNKI, Baidu Scholar, Google Scholar, and ancient materia medica.Trametes Robiniophila Murr (Huaier), a traditional Chinese medicine, has demonstrated significant efficacy in the clinical treatment of various tumors. The primary bioactive constituents of Huaier consist of fungal-derived compounds, including polysaccharides, proteins, ketones, alkaloids, and minerals. The research findings demonstrate that Huaier serves as a reliable adjunctive therapeutic agent by effectively inhibiting cancer cell proliferation, inducing apoptosis in cancer cells, suppressing tumor metastasis, regulating tumor stem cells and immune function. Therefore, it exerts a potent anti-tumor effect when used in conjunction with conventional anti-cancer therapies.The analysis of traditional uses, phytochemical composition, and pharmacological activity reveals that Huaier exhibits significant potential as a medicinal plant with diverse pharmacological effects. Owing to its numerous advantages, Huaier holds immense promise for application in the domains of tumor prevention and treatment, enhancing both survival time and quality of life among cancer patients.Copyright © 2024. Published by Elsevier B.V.