通过抑制钠转运蛋白来显着衰老。
Striking senescence with sodium transporter inhibition.
发表日期：2024 Jul 13
作者：
Bettina Schock, Steven O'Reilly
来源：
TRENDS IN MOLECULAR MEDICINE
摘要：
衰老与多种发病相关，针对这些细胞的治疗目标是一个关键目标。在最近的一项研究中，Katsuumi 等人。发现靶向钠-葡萄糖协同转运蛋白 2 (SGLT2) 通过抑制程序性细胞死亡 1 配体 (PD-L1) 促进衰老细胞的免疫清除，从而促进免疫监视。这可能对许多与年龄相关的疾病产生深远的影响，包括癌症和虚弱。版权所有 © 2024 Elsevier Ltd. 保留所有权利。
Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.Copyright © 2024 Elsevier Ltd. All rights reserved.