自身免疫性疾病的患病率是全球第三大常见疾病，仅次于癌症和心脏病。大量研究表明，长链非编码RNA（lncRNA）在调节人体生长、发育以及多种疾病的发病机制中发挥着关键作用。它的长度超过200个核苷酸，主要参与基因表达的调控。此外，lncRNA 对免疫细胞的发育和激活至关重要，越来越多的研究探索它们与人类自身免疫性疾病的关系。 LncRNA Ifng 反义 RNA 1 (IFNG-AS1) 是免疫系统中的关键调节因子，也称为 NeST 或 TMEVPG1，位于 IFNG 近端并参与其调节。 IFNG-AS1 的失调与多种自身免疫性疾病的发病机制有关。本研究探讨了 IFNG-AS1 在各种自身免疫性疾病中的作用和机制，并考虑其作为治疗靶点的潜力。© 2024。作者获得日本人类细胞学会的独家许可。

The prevalence of autoimmune diseases ranks as the third most common disease category globally, following cancer and heart disease. Numerous studies indicate that long non-coding RNA (lncRNA) plays a pivotal role in regulating human growth, development, and the pathogenesis of various diseases. It is more than 200 nucleotides in length and is mostly involve in the regulation of gene expression. Furthermore, lncRNAs are crucial in the development and activation of immune cells, with an expanding body of research exploring their association with autoimmune disorders in humans. LncRNA Ifng antisense RNA 1 (IFNG-AS1), a key regulatory factor in the immune system, also named NeST or TMEVPG1, is proximally located to IFNG and participates in the regulation of it. The dysregulation of IFNG-AS1 is implicated in the pathogenesis of several autoimmune diseases. This study examines the role and mechanism of IFNG-AS1 in various autoimmune diseases and considers its potential as a therapeutic target.© 2024. The Author(s) under exclusive licence to Japan Human Cell Society.