由于运动和禁食不足等患者因素导致 18F-氟脱氧葡萄糖 (FDG) 生物分布发生改变，这是诊断效果有限的既定原因。此外，已知 G-CSF 等药物会影响骨髓和脾脏对 FDG 的吸收。在这项研究中，我们介绍了一名近期接受高剂量地塞米松的儿科淋巴瘤患者白色脂肪摄取增加的病例，并回顾了有关这种罕见且知之甚少的 FDG 生物分布改变模式的相关文献。一名 14 岁男性患者被诊断为患有 B 细胞淋巴母细胞淋巴瘤的患者在完成诱导化疗方案后不久接受了 FDG-PET/CT 重新分期。图像显示，白色脂肪组织中弥漫性 FDG 摄取，归因于两天前完成的 29 天地塞米松疗程。 7 天后，获得了 FDG 生物分布相对正常化的诊断充分研究。在我们的文献综述中，白色脂肪弥漫性 FDG 摄取的情况很少见，仅在少数病例报告和早期观察性研究中报道过。除了接受皮质类固醇治疗的患者外，其他药物引起的脂肪重塑病例，例如接受高活性抗逆转录病毒治疗的患者，也已被证明具有类似的白色脂肪组织活性增加的模式。皮质类固醇诱导的白色脂肪摄取 FDG 是一种罕见的现象，限制了 FDG-PET/CT 的诊断准确性，并且需要重复成像。目前的证据表明，停用皮质类固醇后至少等待一周就足以减少白色脂肪的摄取并提高诊断准确性。© 2024。作者。

Altered 18F-fluorodeoxyglucose (FDG) biodistribution due to patient factors such as exercise and inadequate fasting are well established causes of limited diagnostic efficacy. In addition, medications such as G-CSF are known to affect uptake of FDG by bone marrow and spleen. In this study, we present a case of increased white adipose uptake in a pediatric lymphoma patient who recently received high dose dexamethasone and review the relevant literature regarding this rare and poorly understood pattern of altered FDG biodistribution.A 14-year-old male patient diagnosed with B-cell lymphoblastic lymphoma underwent FDG-PET/CT for restaging shortly after completing an induction chemotherapy regimen. Images revealed diffuse FDG uptake localizing to white adipose tissue, attributed to the 29-day course of dexamethasone which was completed two days prior. A diagnostically adequate study with relative normalization of FDG biodistribution was obtained seven days later.In our review of the literature, diffuse FDG uptake by white fat is a rare occurrence and has only been reported by a few case reports and early observational studies. In addition to patients receiving corticosteroids, other cases of medication-induced adipose remodeling such as patients receiving highly active antiretroviral therapy have been documented with similar patterns of increased white adipose tissue activity.Corticosteroid-induced white fat uptake of FDG is a rare phenomenon that can limit diagnostic accuracy of FDG-PET/CT and necessitate repeat imaging. Current evidence suggests that a wait period of at least one week after discontinuation of corticosteroids is sufficient to allow for decreased white fat uptake and increased diagnostic accuracy.© 2024. The Author(s).