比较头颈癌 (HNC) 放射治疗 (RT) 前后女性和男性之间的唾液流量。前瞻性观察性多中心队列研究 (OraRad)。在 RT 前以及 RT 后 6 个月和 18 个月时测量受刺激的全唾液流量。RT 前女性 (n = 107) 的平均唾液流量 (95% 置信区间) 为 0.81 (0.71, 0.90) 和 1.20 (1.15) , 1.25) 男性 (n = 391) (p < 0.001); 6个月时，女性为0.34（0.24，0.44），男性为0.50（0.44，0.55）（p= 0.01）； 18 个月时，女性为 0.49 (0.38, 0.59)，男性为 0.70 (0.64, 0.75) (p<0.001)。放疗后女性的中位最低唾液流量为 0.22，男性为 0.35（p<<0.001）。女性（而非男性）较低的最低唾液流量与牙齿缺失的风险增加相关（p = 0.02）。患有 HNC 的女性在 RT 之前和之后的刺激总唾液流量低于男性。放疗后唾液流量低可能是女性牙齿缺失的危险因素。女性 RT 前唾液流量较低，结合其他人群的先前文献表明，一般来说，女性受刺激的唾液流量低于男性。© 2024 John Wiley

To compare salivary flow rates between females and males, before and after radiation therapy (RT) for head and neck cancer (HNC).Prospective observational multicenter cohort study (OraRad). Stimulated whole salivary flow was measured before RT and at 6 and 18 months after RT.Mean (95% confidence interval) salivary flow in g/min before RT was 0.81 (0.71, 0.90) in females (n = 107) and 1.20 (1.15, 1.25) in males (n = 391) (p < 0.001); at 6 months was 0.34 (0.24, 0.44) in females and 0.50 (0.44, 0.55) in males (p = 0.01); at 18 months was 0.49 (0.38, 0.59) in females and 0.70 (0.64, 0.75) in males (p < 0.001). Median nadir salivary flow after RT was 0.22 in females and 0.35 in males (p < 0.001). A lower nadir salivary flow in females, but not males, was associated with an increased risk for tooth failure (p = 0.02).Females with HNC have lower stimulated whole salivary flow than males, before and after RT. Low salivary flow after RT may be a risk factor for tooth failure among females. The lower pre-RT salivary flow rates in females, combined with prior literature in other populations, indicates that, in general, females have lower stimulated salivary flow than males.© 2024 John Wiley & Sons Ltd.