女性唾液流量低于男性，无论头颈癌放疗前后

Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer

ORAL DISEASES

影响因子:2.9

分区:医学3区 / 牙科与口腔外科4区

发表日期:2025 Mar

作者: Rajesh V Lalla, Erika S Helgeson, Komal Virk, Han Lu, Nathaniel S Treister, Thomas P Sollecito, Brian L Schmidt, Lauren L Patton, Alexander Lin, Michael T Brennan

DOI: 10.1111/odi.15068

摘要

旨在比较女性与男性在头颈癌（HNC）放疗（RT）前后的唾液流量。为此，我们进行了一项前瞻性多中心队列研究（OraRad）。刺激性全唾液流量在放疗前、放疗6个月后及18个月后测量。放疗前，女性（n=107）的平均（95%置信区间）唾液流量为0.81（0.71, 0.90）g/分钟，男性（n=391）为1.20（1.15, 1.25）g/分钟（p<0.001）；6个月后，女性为0.34（0.24, 0.44），男性为0.50（0.44, 0.55）（p=0.01）；18个月后，女性为0.49（0.38, 0.59），男性为0.70（0.64, 0.75）（p<0.001）。放疗后最低唾液流量的中位数为女性0.22，男性0.35（p<0.001）。低的最低唾液流量与女性牙齿失败风险增加相关（p=0.02）。研究发现，HNC女性在放疗前后刺激性全唾液流量均低于男性。放疗后低唾液流量可能增加女性牙齿失败的风险。女性放疗前的低唾液流量，加上其他人群的相关研究，表明一般女性的刺激性唾液流量低于男性。

Abstract

To compare salivary flow rates between females and males, before and after radiation therapy (RT) for head and neck cancer (HNC).Prospective observational multicenter cohort study (OraRad). Stimulated whole salivary flow was measured before RT and at 6 and 18 months after RT.Mean (95% confidence interval) salivary flow in g/min before RT was 0.81 (0.71, 0.90) in females (n = 107) and 1.20 (1.15, 1.25) in males (n = 391) (p < 0.001); at 6 months was 0.34 (0.24, 0.44) in females and 0.50 (0.44, 0.55) in males (p = 0.01); at 18 months was 0.49 (0.38, 0.59) in females and 0.70 (0.64, 0.75) in males (p < 0.001). Median nadir salivary flow after RT was 0.22 in females and 0.35 in males (p < 0.001). A lower nadir salivary flow in females, but not males, was associated with an increased risk for tooth failure (p = 0.02).Females with HNC have lower stimulated whole salivary flow than males, before and after RT. Low salivary flow after RT may be a risk factor for tooth failure among females. The lower pre-RT salivary flow rates in females, combined with prior literature in other populations, indicates that, in general, females have lower stimulated salivary flow than males.