非传染性疾病（NCD），包括心血管疾病、癌症、代谢疾病和骨骼疾病，对全球公共卫生构成重大挑战。这些疾病的复杂发病机制与氧化应激和炎症损伤密切相关。核因子红细胞 2 相关因子 2 (Nrf2) 是一种关键的转录因子，在调节抗氧化和抗炎反应中发挥重要作用，以保护细胞免受氧化损伤和炎症介导的损伤。因此，Nrf2靶向疗法有望预防和治疗非传染性疾病。槲皮素 (Que) 是一种广泛使用的黄酮类化合物，具有显着的抗氧化和抗炎特性。它调节 Nrf2 信号通路以改善氧化应激和炎症。 Que 调节线粒体功能、细胞凋亡、自噬和细胞损伤生物标志物，以调节氧化应激和炎症，凸显其作为非传染性疾病治疗剂的功效。在这里，我们首次讨论了 NCD 发病机制与 Nrf2 信号通路之间的密切关联，涉及神经退行性疾病 (NDD)、心血管疾病、癌症、器官损伤和骨损伤。此外，我们还回顾了 Que 在治疗非传染性疾病方面的可用性、药代动力学、药剂学和治疗应用。此外，我们还重点讨论了其临床应用的挑战和前景。由于其 Nrf2 靶向特性，Que 是治疗非传染性疾病的有前途的候选药物。© 2024 作者。

Non-communicable diseases (NCDs), including cardiovascular diseases, cancer, metabolic diseases, and skeletal diseases, pose significant challenges to public health worldwide. The complex pathogenesis of these diseases is closely linked to oxidative stress and inflammatory damage. Nuclear factor erythroid 2-related factor 2 (Nrf2), a critical transcription factor, plays an important role in regulating antioxidant and anti-inflammatory responses to protect the cells from oxidative damage and inflammation-mediated injury. Therefore, Nrf2-targeting therapies hold promise for preventing and treating NCDs. Quercetin (Que) is a widely available flavonoid that has significant antioxidant and anti-inflammatory properties. It modulates the Nrf2 signaling pathway to ameliorate oxidative stress and inflammation. Que modulates mitochondrial function, apoptosis, autophagy, and cell damage biomarkers to regulate oxidative stress and inflammation, highlighting its efficacy as a therapeutic agent against NCDs. Here, we discussed, for the first time, the close association between NCD pathogenesis and the Nrf2 signaling pathway, involved in neurodegenerative diseases (NDDs), cardiovascular disease, cancers, organ damage, and bone damage. Furthermore, we reviewed the availability, pharmacokinetics, pharmaceutics, and therapeutic applications of Que in treating NCDs. In addition, we focused on the challenges and prospects for its clinical use. Que represents a promising candidate for the treatment of NCDs due to its Nrf2-targeting properties.© 2024 The Authors.