关于槲皮素在非传染性疾病中的治疗潜力的新观点：靶向NRF2来抵消氧化应激和炎症
New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
影响因子:8.90000
分区:医学1区 Top / 药学1区
发表日期:2024 Jun
作者:
Li Zhang, Li-Yue Xu, Fei Tang, Dong Liu, Xiao-Lan Zhao, Jing-Nan Zhang, Jia Xia, Jiao-Jiao Wu, Yu Yang, Cheng Peng, Hui Ao
摘要
非传染性疾病（NCD），包括心血管疾病，癌症，代谢疾病和骨骼疾病，对全球公共卫生构成了重大挑战。这些疾病的复杂发病机理与氧化应激和炎症损伤密切相关。核因子红细胞2相关因子2（NRF2）是关键转录因子，在调节抗氧化剂和抗炎反应中起着重要作用，以保护细胞免受氧化损伤和炎症介导的损伤。因此，NRF2靶向疗法有望预防和治疗NCD。槲皮素（QUE）是一种可广泛的类黄酮，具有显着的抗氧化剂和抗炎特性。它调节了NRF2信号通路，以改善氧化应激和炎症。 Que调节线粒体功能，凋亡，自噬和细胞损伤生物标志物，以调节氧化应激和炎症，突出显示其作为对NCD的治疗剂的功效。在这里，我们首次讨论了NCD发病机理与NRF2信号通路之间的密切关联，该途径涉及神经退行性疾病（NDDS），心血管疾病，癌症，器官损伤和骨损伤。此外，我们回顾了Que在治疗NCD中的可用性，药代动力学，药物和治疗应用。此外，我们专注于临床使用的挑战和前景。 QUE代表了由于其NRF2靶向特性而导致的NCD治疗的有前途的候选人。
Abstract
Non-communicable diseases (NCDs), including cardiovascular diseases, cancer, metabolic diseases, and skeletal diseases, pose significant challenges to public health worldwide. The complex pathogenesis of these diseases is closely linked to oxidative stress and inflammatory damage. Nuclear factor erythroid 2-related factor 2 (Nrf2), a critical transcription factor, plays an important role in regulating antioxidant and anti-inflammatory responses to protect the cells from oxidative damage and inflammation-mediated injury. Therefore, Nrf2-targeting therapies hold promise for preventing and treating NCDs. Quercetin (Que) is a widely available flavonoid that has significant antioxidant and anti-inflammatory properties. It modulates the Nrf2 signaling pathway to ameliorate oxidative stress and inflammation. Que modulates mitochondrial function, apoptosis, autophagy, and cell damage biomarkers to regulate oxidative stress and inflammation, highlighting its efficacy as a therapeutic agent against NCDs. Here, we discussed, for the first time, the close association between NCD pathogenesis and the Nrf2 signaling pathway, involved in neurodegenerative diseases (NDDs), cardiovascular disease, cancers, organ damage, and bone damage. Furthermore, we reviewed the availability, pharmacokinetics, pharmaceutics, and therapeutic applications of Que in treating NCDs. In addition, we focused on the challenges and prospects for its clinical use. Que represents a promising candidate for the treatment of NCDs due to its Nrf2-targeting properties.