静脉血栓栓塞 (VTE) 与各种长期并发症相关。我们的目的是研究 VTE 诊断时的临床特征与 3 个月和 12 个月后功能限制的关系。我们对 VTE 患者进行了一项前瞻性队列研究，排除了癌症患者、怀孕期、产后期。在诊断后 21 天内、3 个月和 12 个月（前瞻性）以及诊断前 1 个月（回顾性）使用 VTE 后功能状态 (PVFS) 量表（范围，0-4）评估功能限制。仅对接受抗凝治疗的患者进行了十二个月的随访。我们为 3 个月和 12 个月的随访拟合了 2 个比例优势逻辑回归模型，并计算了优势比 (OR) 和 95% 引导百分位数置信区间 (CI)。我们纳入了 307 名患者（42% 为女性，中位年龄 55.6 岁） ），研究纳入时中位值 (IQR) PVFS 量表等级为 2 (2-3)，诊断前为 0 (0-0)。 3个月后，269名患者的PVFS量表分级为1（0-2）。女性（OR，2.15；95% CI，1.26-4.14）、体重指数（OR 每增加 1 kg/m2，1.05；95% CI，1.00-1.10）、基线时的功能限制和年龄较大与功能限制。 12 个月后，124 名患者的 PVFS 量表分级为 1 (0-2)。女性（OR，4.47；95% CI，2.11-16.00）、心血管/肺部疾病史（OR，2.36；95% CI，1.01-6.89）和基线时的功能限制与功能限制相关。 VTE 患者在诊断后 3 个月和 12 个月有所改善，但没有恢复到 VTE 前的值。我们确定了临床特征，可以帮助识别 VTE 后存在持续功能限制风险的患者。© 2024 作者。

Venous thromboembolism (VTE) is associated with various long-term complications.We aimed to investigate the association of clinical characteristics at VTE diagnosis with functional limitations 3 and 12 months afterward.We conducted a prospective cohort study of VTE patients, excluding patients with cancer, pregnancy, and postpartum period. Functional limitations were assessed with the post-VTE functional status (PVFS) scale (range, 0-4) within 21 days of diagnosis, after 3 and 12 months (prospectively), and 1 month before diagnosis (retrospectively). Twelve-month follow-up was only performed in patients on anticoagulation. We fitted 2 proportional odds logistic regression models for the 3- and 12-month follow-ups and computed odds ratios (ORs) with 95% bootstrap percentile confidence intervals (CIs).We included 307 patients (42% female, median age 55.6 years) with a median (IQR) PVFS scale grade of 2 (2-3) at study inclusion and 0 (0-0) before diagnosis. After 3 months, PVFS scale grade in 269 patients was 1 (0-2). Female sex (OR, 2.15; 95% CI, 1.26-4.14), body mass index (OR per 1 kg/m2 increase, 1.05; 95% CI, 1.00-1.10), functional limitations at baseline, and older age were associated with functional limitations. After 12 months, PVFS scale grade in 124 patients was 1 (0-2). Female sex (OR, 4.47; 95% CI, 2.11-16.00), history of cardiovascular/pulmonary disease (OR, 2.36; 95% CI, 1.01-6.89), and functional limitations at baseline were associated with functional limitations.Functional limitations in VTE patients improved 3 and 12 months after diagnosis but did not return to pre-VTE values. We identified clinical characteristics that could help identify patients at risk of persisting functional limitations after VTE.© 2024 The Author(s).