化脓性关节炎、痤疮、坏疽性脓皮病和化脓性汗腺炎（PAPASH）；化脓性关节炎、坏疽性脓皮病 (PG) 和痤疮； PG，痤疮，化脓性汗腺炎； PG、痤疮、脊柱关节炎 (PASS) 都是具有相似发病机制的一系列自身炎症性疾病的一部分。它们与脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白 1 的各种突变有关，导致先天免疫系统失调以及白细胞介素 (IL)-1、IL-17 和 IL-23 以及肿瘤坏死因子 (TNF) 的过度产生。 )-α。用生物制剂靶向这些细胞因子在治疗中发挥着重要作用。在这里，我们描述了一位患有 PAPASH 综合征的年轻男性的病例，他接受了 TNF-α 和 IL-1 抑制剂的治疗。版权所有 © 2024，Ahmad 等人。

Pyogenic arthritis, acne, pyoderma gangrenosum, and suppurative hidradenitis (PAPASH); pyogenic arthritis, pyoderma gangrenosum (PG), and acne; PG, acne, hidradenitis suppurativa; and PG, acne, spondylarthritis (PASS) are all part of a spectrum of autoinflammatory disorders that share similar pathogenesis. They are related to various mutations in the proline-serine-threonine phosphatase interacting protein 1, leading to dysregulation of the innate immune system and overproduction of interleukin (IL)-1, IL-17, and IL-23 and tumor necrosis factor (TNF)-α. Targeting these cytokines with biologics plays an important role in treatment. Here, we are describing the case of a young male with PAPASH syndrome who was treated with TNF-α and IL-1 inhibitor.Copyright © 2024, Ahmad et al.