microRNA介导的癌症免疫细胞的代谢调节：更新的综述
MicroRNA-mediated metabolic regulation of immune cells in cancer: an updated review
影响因子:5.90000
分区:医学2区 / 免疫学2区
发表日期:2024
作者:
Sepideh Chowdary Khameneh, Sara Razi, Ramin Lashanizadegan, Sanaz Akbari, Masoud Sayaf, Karimeh Haghani, Salar Bakhtiyari
摘要
对免疫代谢的研究研究了免疫细胞如何调节其代谢以保持最佳性能，已成为癌症免疫学的重点领域。该领域的最新进展强调了代谢与免疫细胞功能之间的复杂联系，强调了进一步研究的需求。 MicroRNA（miRNA）因其转录后调节基因表达和影响各种生物学过程的能力而引起了人们的关注，包括免疫功能和癌症进展。尽管仍在探索miRNA在免疫代谢中的作用，但最近的研究表明，它们对免疫细胞的代谢活性的重要影响，例如巨噬细胞，T细胞，B细胞，B细胞和树突状细胞，尤其是在癌症的情况下。免疫细胞代谢破坏是癌症进展的标志，而miRNA与此过程有关。了解miRNA对免疫细胞代谢对癌症的确切影响对于免疫治疗方法的发展至关重要。靶向miRNA可能有可能产生突破性的癌症免疫疗法以重塑肿瘤环境并改善治疗结果。总而言之，对各种癌症中免疫细胞代谢的关键调节剂的识别为精炼癌症免疫疗法提供了有希望的潜力。进一步研究miRNA如何影响免疫细胞代谢可以鉴定出新的治疗靶标，并导致创新的癌症免疫疗法的发展。
Abstract
The study of immunometabolism, which examines how immune cells regulate their metabolism to maintain optimal performance, has become an important area of focus in cancer immunology. Recent advancements in this field have highlighted the intricate connection between metabolism and immune cell function, emphasizing the need for further research. MicroRNAs (miRNAs) have gained attention for their ability to post-transcriptionally regulate gene expression and impact various biological processes, including immune function and cancer progression. While the role of miRNAs in immunometabolism is still being explored, recent studies have demonstrated their significant influence on the metabolic activity of immune cells, such as macrophages, T cells, B cells, and dendritic cells, particularly in cancer contexts. Disrupted immune cell metabolism is a hallmark of cancer progression, and miRNAs have been linked to this process. Understanding the precise impact of miRNAs on immune cell metabolism in cancer is essential for the development of immunotherapeutic approaches. Targeting miRNAs may hold potential for creating groundbreaking cancer immunotherapies to reshape the tumor environment and improve treatment outcomes. In summary, the recognition of miRNAs as key regulators of immune cell metabolism across various cancers offers promising potential for refining cancer immunotherapies. Further investigation into how miRNAs affect immune cell metabolism could identify novel therapeutic targets and lead to the development of innovative cancer immunotherapies.