microRNA介导的免疫细胞代谢调控在癌症中的作用：最新综述
MicroRNA-mediated metabolic regulation of immune cells in cancer: an updated review
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影响因子:5.9
分区:医学2区 / 免疫学2区
发表日期:2024
作者:
Sepideh Chowdary Khameneh, Sara Razi, Ramin Lashanizadegan, Sanaz Akbari, Masoud Sayaf, Karimeh Haghani, Salar Bakhtiyari
DOI:
10.3389/fimmu.2024.1424909
摘要
免疫代谢（immunometabolism）研究关注免疫细胞如何调节其代谢以维持最佳功能，已成为癌症免疫学中的一个重要领域。该领域的最新进展强调了代谢与免疫细胞功能之间错综复杂的联系，指出需要进一步的研究。微小RNA（miRNAs）因其在转录后调控基因表达和影响多种生物过程（包括免疫功能和癌症进展）中的能力而受到关注。虽然miRNAs在免疫代谢中的作用尚在探索中，近期研究已显示它们对免疫细胞（如巨噬细胞、T细胞、B细胞和树突状细胞）代谢活性的显著影响，尤其是在癌症环境中。免疫细胞代谢的紊乱是癌症进展的标志之一，miRNAs与此过程密切相关。理解miRNAs在癌症中对免疫细胞代谢的具体影响对于开发免疫治疗策略至关重要。靶向miRNAs可能为创新癌症免疫治疗提供潜在途径，以重塑肿瘤微环境并改善治疗效果。总之，识别miRNAs作为多种癌症中免疫细胞代谢的关键调控因子，为优化癌症免疫疗法提供了有希望的前景。进一步研究miRNAs如何影响免疫细胞代谢，可能揭示新的治疗靶点，促进创新癌症免疫治疗的发展。
Abstract
The study of immunometabolism, which examines how immune cells regulate their metabolism to maintain optimal performance, has become an important area of focus in cancer immunology. Recent advancements in this field have highlighted the intricate connection between metabolism and immune cell function, emphasizing the need for further research. MicroRNAs (miRNAs) have gained attention for their ability to post-transcriptionally regulate gene expression and impact various biological processes, including immune function and cancer progression. While the role of miRNAs in immunometabolism is still being explored, recent studies have demonstrated their significant influence on the metabolic activity of immune cells, such as macrophages, T cells, B cells, and dendritic cells, particularly in cancer contexts. Disrupted immune cell metabolism is a hallmark of cancer progression, and miRNAs have been linked to this process. Understanding the precise impact of miRNAs on immune cell metabolism in cancer is essential for the development of immunotherapeutic approaches. Targeting miRNAs may hold potential for creating groundbreaking cancer immunotherapies to reshape the tumor environment and improve treatment outcomes. In summary, the recognition of miRNAs as key regulators of immune cell metabolism across various cancers offers promising potential for refining cancer immunotherapies. Further investigation into how miRNAs affect immune cell metabolism could identify novel therapeutic targets and lead to the development of innovative cancer immunotherapies.