PD-1/PD-L1 相互作用的光激活偶氮苯肽抑制剂。
Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction.
发表日期：2024 Jul 15
作者：
Deanne Hayward, Zoë R Goddard, Marco M D Cominetti, Mark Searcey, Andrew M Beekman
来源：
Cellular & Molecular Immunology
摘要：
抑制PD-1/PD-L1蛋白-蛋白相互作用是癌症免疫治疗的关键。抗体在临床领域占据主导地位，但价格昂贵、适用性有限且具有免疫副作用。我们开发了一种光控偶氮苯肽，仅在顺式异构体时选择性抑制 PD-1/PD-L1 相互作用。活性在体外和细胞测定中得到证实。
Inhibiting the PD-1/PD-L1 protein-protein interaction is a key immunotherapy for cancer. Antibodies dominate the clinical space but are costly, with limited applicability and immune side effects. We developed a photo-controlled azobenzene peptide that selectively inhibits the PD-1/PD-L1 interaction when in the cis isomer only. Activity is demonstrated in in vitro and cellular assays.