潜在的纳米药物应用和丝孔降低的纳米 - 萨米亚的物理化学性质

在本文中，我们描述了氧化物纳米颗粒（HT-SM2O3 NPS）的生物形成，通过施用丝烯二氧化碳的水果提取物作为环保螯合剂。在生物医学应用中，制备的NP具有各种物理化学特性和潜力。 X射线衍射（XRD）模式显示出尖锐的峰值，这些峰与粉末衍射标准委员会（JCPDS）卡的联合委员会证实了。 00-042-1464。从Debye-Scherrer近似获得的结晶石大小和Williamson-Hall（W-H）图分别为28.73和69.3 nm。通过采用kubelka-munk（K-M）函数来计算光学带隙，发现〜4.58 eV。在121、351、424-和561 cm-1时观察到拉曼移位。光致发光（PL）光谱显示两个位于360和540 nm处的主要峰。 HT-SM2O3纳米颗粒（NPS）的高分辨率透射电子显微镜（HR-TEM）分析表明，它们主要具有球形至立方体形状。此外，所选区域电子衍射（SAED）图案呈现出斑点环，表明在这些NP中的结晶度很高。使用不同的生物测定方法研究了潜在的纳米医学应用。抗氧化活性在1000μg/mL时表现出45.71％±1.13％。盐水虾致死性测定法显示，在1000μg/ml时，最高的细胞毒性为46.67％±3.33％，LC50值为1081μg/ml。 HT-SM2O3 NPS在1000μg/mL时表现出抑制血管生成（20.41％±1.18％）。 MTT分析结果表明HT-SM2O3 NPS对细胞系具有抑制作用。具体而言，这些NP对3T3细胞的IC50值为104.6μg/ml。针对MCF-7细胞，NP的IC50值为413.25μg/ml。另外，在抑制乙酰胆碱酯酶（ACHE）时，新合成的NP显示出320μg/ml的IC50值。通过α-葡萄糖苷酶和α-淀粉酶抑制测定的抗糖尿病评估显示，计算了α-葡萄糖苷酶的IC50值为380μg/ml，α-淀粉酶的IC50值为380μg/ml，952μg/mL的IC50值被计算出来。总体而言，我们的研究表明，SM2O3 NP具有适度的抗癌，胆碱酯酶抑制和抗糖尿病潜力，但需要进一步评估。研究重点：在这项工作中，纳米 - 萨马里亚是使用环保和绿色方法合成的。使用拉曼，HR-TEM，FTIR，DRS，XRD等技术对纳米颗粒进行了表征，并使用多种糖尿病，阿尔茨海默氏症和癌症的多种体外生物测定研究对应用进行了研究。纳米 - 萨马里亚揭示了潜在生物医学应用的良好潜力。

Herein we described the biofabrication of samarium oxide nanoparticles (HT-Sm2O3 NPs) by applying the aqueous fruit extract of Hyphaene thebaica was utilized as an eco-friendly chelating agent. The prepared NPs were subjected to various physicochemical properties and potential in biomedical applications. X-ray Diffraction (XRD) pattern revealed sharp peaks that corroborated with the Joint Committee on Powder Diffraction Standards (JCPDS) card no. 00-042-1464. Crystallite size obtained from Debye-Scherrer approximation and Williamson-Hall (W-H) plot was 28.73 and 69.3 nm, respectively. Optical bandgap was calculated by employing Kubelka-Munk (K-M) function and was found to be ~4.58 eV. Raman shift was observed at 121, 351, 424-, and 561 cm-1. Photoluminescence (PL) spectra revealed two major peaks positioned at 360 and 540 nm. The high-resolution transmission electron microscopy (HR-TEM) analysis of HT-Sm2O3 nanoparticles (NPs) showed that they predominantly have spherical to cuboidal shapes. Additionally, the selected area electron diffraction (SAED) pattern presented spotty rings, indicating a high level of crystallinity in these NPs. The potential nanomedicine applications were studied using diverse bioassays using different treatments. The antioxidant activity demonstrated 45.71% ± 1.13% inhibition at 1000 μg/mL. Brine shrimp lethality assay revealed the highest cytotoxicity of 46.67% ± 3.33% at 1000 μg/mL and LC50 value of 1081 μg/mL. HT-Sm2O3 NPs exhibited inhibition of angiogenesis (20.41% ± 1.18%) at of 1000 μg/mL. MTT assay results indicated that HT-Sm2O3 NPs exhibit inhibitory effects on cell lines. Specifically, these NPs showed an IC50 value of 104.6 μg/mL against 3T3 cells. Against MCF-7 cells, the NPs demonstrated an IC50 value of 413.25 μg/mL. Additionally, in the inhibition of acetylcholinesterase (AChE), the newly synthesized NPs showed an IC50 value of 320 μg/mL. The antidiabetic assessment through α-glucosidase and α-amylase inhibition assays revealed, an IC50 value of 380 μg/mL for α-glucosidase and 952 μg/mL for α-amylase was calculated. Overall, our study suggested that the Sm2O3 NPs possess moderate anticancer, cholinesterase inhibition, and antidiabetic potential, however, needs further assessment. RESEARCH HIGHLIGHTS: In this work, nano-samaria is synthesized using an eco-friendly and green approach. The nanoparticles were characterized using techniques such as Raman, HR-TEM, FTIR, DRS, XRD, and so on, and the applications were studied using multiple in vitro bioassays for Diabetes, Alzheimer, and Cancer. The nano-samaria revealed good potential for potential biomedical applications.