麝香肌无力的癌症频率和副塑性病因的组织学证据
Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology
影响因子:7.70000
分区:医学1区 Top / 临床神经病学1区 神经科学1区
发表日期:2024 Nov
作者:
Silvia Falso, Marco Gessi, Sofia Marini, Roberta Benvenuto, Eleonora Sabatelli, Antonio D'Amati, Martina Marini, Amelia Evoli, Raffaele Iorio
摘要
尚未探索肌肉特异性激酶肌无力的肌无力（MUSK-MG）的癌症频率，导致Musk IgG形成的机制仍然难以捉摸。我们旨在探索Musk-MG患者的癌症频率，并评估该队列中2个肿瘤的癌细胞中的麝香表达。肿瘤标本的免疫组织化学揭示了原发性纵隔B细胞淋巴瘤和子宫内膜癌在癌细胞中麝香的表达。招募了21名男性和73名女性。 94例患者中有13例发生了15种癌症（13.8％）。麝香-mg发作时，癌症患者的年龄较大。 Ann Neurol 2024; 96：1020-1025。
Abstract
Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset. ANN NEUROL 2024;96:1020-1025.