MuSK肌肉特异性酪氨酸激酶肌无力的癌症发生频率及类肿瘤病因的组织学证据
Cancer Frequency in MuSK Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology
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影响因子:7.7
分区:医学1区 Top / 临床神经病学1区 神经科学1区
发表日期:2024 Nov
作者:
Silvia Falso, Marco Gessi, Sofia Marini, Roberta Benvenuto, Eleonora Sabatelli, Antonio D'Amati, Martina Marini, Amelia Evoli, Raffaele Iorio
DOI:
10.1002/ana.27033
摘要
肌肉特异性酪氨酸激酶肌无力（MuSK-MG）中的癌症发生频率尚未被系统研究，导致MuSK IgG形成机制仍不清楚。我们旨在探讨MuSK-MG患者中的癌症发生频率，并评估在该队列中发生的两个肿瘤中的MuSK表达。对肿瘤标本进行免疫组化，发现MuSK在原发性纵隔B细胞淋巴瘤和子宫内膜癌的癌细胞中表达。有21名男性和73名女性被纳入研究。在94名患者中，有13名（13.8%）发生了15例癌症。癌症患者在MuSK-MG发病时年龄明显较大。ANN NEUROL 2024;96:1020-1025.
Abstract
Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset. ANN NEUROL 2024;96:1020-1025.