肌肉特异性激酶重症肌无力 (MuSK-MG) 的癌症发生率尚未被探索，导致 MuSK IgG 形成的机制仍然难以捉摸。我们的目的是探索 MuSK-MG 患者的癌症频率，并评估该队列中发生的 2 个肿瘤的癌细胞中 MuSK 的表达。肿瘤标本的免疫组织化学显示原发性纵隔 B 细胞淋巴瘤和子宫内膜癌的癌细胞中 MuSK 的表达。登记了 21 名男性和 73 名女性。 94 名患者中有 13 名患有 15 种癌症（13.8%）。 MuSK-MG 发病时癌症患者的年龄明显较大。 ANN NEUROL 2024。© 2024 作者。 《神经病学年鉴》由 Wiley periodicals LLC 代表美国神经病学协会出版。

Cancer frequency in muscle-specific kinase myasthenia gravis (MuSK-MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK-MG patients and to assess MuSK expression in cancer cells from 2 tumors occurred in this cohort. Immunohistochemistry on tumor specimens revealed the expression of MuSK in the cancer cells from primary mediastinal B cell lymphoma and endometrial carcinoma. Twenty-one males and 73 females were enrolled. Fifteen cancers occurred in 13 of 94 patients (13.8%). Patients with cancer were significantly older at time of MuSK-MG onset. ANN NEUROL 2024.© 2024 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.