脑膜淋巴管（MLV）在清除大脑毒素方面发挥着重要作用。开发刺激MLV功能的创新技术是治疗与MLV异常相关的各种脑部疾病（包括阿尔茨海默病和帕金森病、脑肿瘤、脑外伤和颅内出血）的一个有前途的方向。睡眠是大脑排水过程最活跃的自然状态。因此，在睡眠期间刺激大脑引流和 MLV 可能具有最显着的治疗效果。然而，目前还不存在这样的商业技术。这项研究提出了一种在脑电图 (EEG) 睡眠控制下的新型便携式经颅光生物调节 (tPBM) 技术，旨在通过光刺激去除老年 BALB/c 小鼠大脑中的毒素（例如可溶性淀粉样蛋白 (Aβ)）。能够比较不同光学资源的治疗效果。该技术可以在家庭笼子的自然条件下使用，无需麻醉，保持小鼠的运动活动。这些数据为开发非侵入性和临床上有前景的光技术开辟了新的前景，用于纠正 MLV 功能和大脑引流过程中与年龄相关的变化，并有效地清除脑组织中的代谢物和毒素。该技术既可用于睡眠大脑功能的临床前研究，也可用于开发与睡眠相关的大脑疾病的临床相关治疗方法。

The meningeal lymphatic vessels (MLVs) play an important role in the removal of toxins from the brain. The development of innovative technologies for the stimulation of MLV functions is a promising direction in the progress of the treatment of various brain diseases associated with MLV abnormalities, including Alzheimer's and Parkinson's diseases, brain tumors, traumatic brain injuries, and intracranial hemorrhages. Sleep is a natural state when the brain's drainage processes are most active. Therefore, stimulation of the brain's drainage and MLVs during sleep may have the most pronounced therapeutic effects. However, such commercial technologies do not currently exist. This study presents a new portable technology of transcranial photobiomodulation (tPBM) under electroencephalographic (EEG) control of sleep designed to photo-stimulate removal of toxins (e.g., soluble amyloid beta (Aβ)) from the brain of aged BALB/c mice with the ability to compare the therapeutic effectiveness of different optical resources. The technology can be used in the natural condition of a home cage without anesthesia, maintaining the motor activity of mice. These data open up new prospects for developing non-invasive and clinically promising photo-technologies for the correction of age-related changes in the MLV functions and brain's drainage processes and for effectively cleansing brain tissues from metabolites and toxins. This technology is intended both for preclinical studies of the functions of the sleeping brain and for developing clinically relevant treatments for sleep-related brain diseases.