相对较少的研究调查了基于康复的身体活动疗法对老年晚期癌症患者的治疗效果。本研究评估了康复医生制定的个性化精确和结构化运动干预措施对老年晚期癌症患者的疲劳、生活质量 (QOL) 和体力活动的影响。入院康复科后，老年癌症患者分为接受常规对症支持治疗（SST）或体力活动治疗加常规对症支持治疗（PAT）的组。 SST组给予对症支持治疗，自行锻炼，症状改善后居家观察。 PAT组被要求在SST的同时进行体育锻炼，每周5天，每天30分钟中等强度的锻炼，4周后出院，并指导继续院外锻炼。 4 周和 8 周时的癌症相关性疲劳 (CRF) 是该研究的主要终点，次要终点包括患者的生活质量、体力活动和运动坚持率。共纳入 65 名患者； 37人（56.92%）选择进入PAT组，28人（43.08%）选择进入SST组。治疗 4 周和 8 周后，PAT 组的 CRF 缓解和 QOL 改善明显优于 SST 组 (p < 0.05)，而两个治疗组之间的总体健康状况没有差异 (T1：p = 0.84； T2：p = 0.92）。 PAT 组在 T1 和 T2 时的轻度体力活动显着增加（T1：p = 0.03；T2：p = 0.005）。在T2时间点，PAT组表现出较高的中等强度体力活动参与水平以及较高的休闲活动总得分（p<0.05）。 33名患者（94.29%）在住院期间完成了PAT锻炼计划。仅4例（12.12%）患者达到中等强度运动，其余29例（87.88%）患者在运动强度降低后仍能继续运动。康复团队制定的精准、个体化的运动干预措施可有效改善患者的运动习惯。降低 CRF 和改善 QOL，以及改变与体力活动相关的行为。© 2024。作者。

Relatively few studies have investigated the effects of rehabilitation-based physical activity therapy as a treatment for older patients with advanced cancer. This study evaluated the effects of individualized precise and structured exercise interventions, prescribed by a rehabilitation physician, on fatigue, quality of life (QOL), and physical activity in older patients with advanced cancer.After admission to the rehabilitation department, older cancer patients were divided into groups receiving conventional symptomatic supportive therapy (SST) or physical activity therapy plus conventional symptomatic supportive therapy (PAT). The SST group was given symptomatic supportive treatment, exercised on their own, and were observed at home after their symptoms improved. The PAT group was required to implement physical exercise along with SST, involving 30 min of moderate-intensity exercise per day and 5 days per week, and were discharged after 4 weeks and instructed to continue to exercise outside the hospital. Cancer-related fatigue (CRF) at 4 and 8 weeks was the primary endpoint of the study, while the secondary endpoints included patients' QOL, physical activity, and exercise adherence rate.Sixty-five patients were included; 37 (56.92%) chose to enter the PAT group, and 28 (43.08%) chose to enter the SST group. After 4 and 8 weeks of treatment, CRF relief and QOL improvement were significantly better in the PAT group than in the SST group (p < 0.05), whereas global health status did not differ between the two treatment groups (T1: p = 0.84; T2: p = 0.92). Mild physical activity significantly increased for the PAT group at T1 and T2 (T1: p = 0.03; T2: p = 0.005). At the T2 time point, the PAT group exhibited a higher level of participation in moderate-intensity physical activities as well as a higher total leisure activity score (p < 0.05). Thirty-three patients (94.29%) completed the PAT exercise program during hospitalization. Only four (12.12%) patients achieved moderate-intensity exercise, while the other 29 (87.88%) patients were able to continue exercising after their exercise intensity was decreased.Implementation of precise and individualized exercise interventions, prescribed by the rehabilitation team, can lead to the reduction of CRF and improvement of QOL, and change in behavior related to physical activity.© 2024. The Author(s).