本研究旨在调查正常宫颈细胞和宫颈癌前/恶性病变中 HPV 51 和 59 的序列变异，以了解伊朗流行的 HPV 51 和 HPV 59 的常见变异。为此，我们使用半 PCR 技术对 85 个感染 HPV 51 或 HPV 59 的样本进行了研究，以扩增 E6 基因，然后进行测序。我们的研究结果表明，A 谱系和 B 谱系分别在 80.4% 和 19.6% 的 HPV 51 阳性病例中检出。在感染 HPV 59 的样本中，32.2% 属于 A 谱系，67.8% 属于 B 谱系。总之，我们的结果表明 HPV 51 的 A 谱系和 HPV 59 的 B 谱系在伊朗更为普遍和分布。© 2024作者获得 Springer Science Business Media, LLC（Springer Nature 的一部分）的独家许可。

The current study aimed to investigate the sequence variations of HPV 51 and 59 in normal cervical cells and premalignant/malignant lesions of the cervix to know the common variants of HPV 51 and HPV 59 circulating in Iran. To do this, eighty-five samples that were infected by HPV 51 or HPV 59 were investigated using hemi-PCR to amplify the E6 gene followed by sequencing. Our findings indicated that lineages A and B were detected in 80.4% and 19.6% of HPV 51-positive cases, respectively. Among samples infected with HPV 59, 32.2% belonged to lineage A and 67.8% were classified with lineage B. In conclusion, our results showed that lineage A of HPV 51 and lineage B of HPV 59 are more prevalent and distributed in Iran.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.