骨髓源性抑制细胞 (MDSC) 是源自骨髓干细胞的异质细胞群。在自身免疫性疾病、过敏、感染和癌症等病理条件下，正常的骨髓生成发生改变，有利于 MDSC 的形成。 MDSC 首次被证明可以在各种趋化因子和细胞因子的帮助下通过免疫抑制来促进癌症的发生和进展。最近，各种研究表明，MDSC 根据生理和病理条件发挥两种不同的作用。 MDSC 在自身免疫性疾病（如葡萄膜视网膜炎、多发性硬化症、类风湿性关节炎、强直性脊柱炎、1 型糖尿病、自身免疫性肝炎、炎症性肠病、斑秃和系统性红斑狼疮）、过敏和器官移植中发挥保护作用。然而，它们在感染和各种癌症中发挥负面作用。 MDSC 的多种免疫抑制功能和机制已在不同疾病条件下得到确定。这篇综述全面讨论了 MDSC 与各种病理状况之间的关联，并简要描述了治疗方法。© 2024。韩国药学会。

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that originate from bone marrow stem cells. In pathological conditions, such as autoimmune disorders, allergies, infections, and cancer, normal myelopoiesis is altered to facilitate the formation of MDSCs. MDSCs were first shown to promote cancer initiation and progression by immunosuppression with the assistance of various chemokines and cytokines. Recently, various studies have demonstrated that MDSCs play two distinct roles depending on the physiological and pathological conditions. MDSCs have protective roles in autoimmune disorders (such as uveoretinitis, multiple sclerosis, rheumatoid arthritis, ankylosing spondylitis, type 1 diabetes, autoimmune hepatitis, inflammatory bowel disease, alopecia areata, and systemic lupus erythematosus), allergies, and organ transplantation. However, they play negative roles in infections and various cancers. Several immunosuppressive functions and mechanisms of MDSCs have been determined in different disease conditions. This review comprehensively discusses the associations between MDSCs and various pathological conditions and briefly describes therapeutic approaches.© 2024. The Pharmaceutical Society of Korea.