本研究旨在探讨基于正念的认知疗法（MBCT）对抑郁症患者抑郁症状、脑电位和神经免疫炎症因子的疗效。根据纳入标准将64例符合条件的患者随机分为对照组和对照组。观察组,每组 32 例。对照组接受常规治疗,观察组在常规治疗基础上接受MBCT。测量两组患者抑郁症状、脑电位、神经免疫炎症因子。治疗后汉密尔顿抑郁量表评分、肿瘤坏死因子α、白细胞介素6水平下降,世界卫生组织生活质量量表评分两组的反应执行得分总数和 5-羟色胺水平均有所增加。此外，汉密尔顿抑郁评定量表评分、肿瘤坏死因子α和白细胞介素6水平下降更为显着，而世界卫生组织生活质量量表评分、响应执行评分总数和5-羟色胺水平则上升观察组较对照组更显着（P<0.01）。此外，观察组潜伏期较对照组短，波幅较长（P < 0.01）。与常规治疗相比，MBCT联合常规治疗可有效减轻抑郁症状，抑制炎症反应，并优化对目标刺激的注意力和反应，值得广泛的临床实施。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

This study was aimed to investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) on depressive symptoms, brain potential, and neuroimmunoinflammatory factors in patients with depression.Sixty-four eligible patients according to the inclusion criteria were randomly divided into the control group and the observation group, with 32 patients in each group. The control group received conventional therapy, while the observation group received MBCT on top of conventional therapy. The depressive symptoms, brain potential, and neuroimmunoinflammatory factors were measured in the two groups.After treatment, the Hamilton Depression Rating Scale score, tumor necrosis factor α, and interleukin-6 levels were decreased, while the World Health Organization Quality of Life Scale score, total number of response execution score, and 5-hydroxy tryptamine level were increased in both groups. Moreover, the Hamilton Depression Rating Scale score, tumor necrosis factor α, and interleukin-6 levels were decreased more significantly, while the World Health Organization Quality of Life Scale score, total number of response execution score, and 5-hydroxy tryptamine level were increased more significantly in the observation group compare to the control group ( P < 0.01). In addition, the latency in the observation group was shorter and the amplitude was longer than those in the control group ( P < 0.01).Compared with conventional therapy, the use of MBCT combined with conventional therapy can effectively reduce depressive symptoms, suppresses inflammatory responses, and optimize attention and response to target stimulation and is worthy of wide clinical implementation.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.