高白细胞介素 8 (IL-8) 水平与肺癌预后不良有关，但缺乏确凿的数据。2023 年 4 月 1 日，从电子数据库中进行了全面检索，重点关注 IL-8 表达评估的研究总生存期 (OS)、无进展生存期 (PFS) 和无病生存期 (DFS) 的风险比 (HR) 和 95% 置信区间 (CI) 的可用性或用于估计的充足数据。然后，我们检查了来自癌症基因组图谱 (TCGA) 数据集的 IL-8 和 CXCR1 RNA-seq 数据，并将这些数据与 OS 相关联。在 2655 条生成的记录中，10 篇手稿涉及非小细胞肺癌和小细胞肺癌癌症，被纳入分析中。两份手稿和一项研究分别包括两个和三个不同的队列，总共 14 组患者。总体而言，4 个队列评估了接受化疗的患者、3 个队列免疫治疗、2 个队列手术患者和 4 个队列其他治疗患者的 IL-8 水平；由于缺乏治疗类型，1 个队列被删除。 OS 分析中包含的 12 个队列显示，与 IL-8 水平低的患者相比，IL-8 水平高的患者的 OS 概率较低（HR=1.75，95% CI 1.36-2.26）。在可用于 PFS 分析的 8 个队列中，未观察到高 IL-8 水平和低 IL-8 水平的患者之间存在显着差异。根据治疗进行的敏感性分析显示，接受化疗或免疫治疗的患者的 PFS 和 OS 存在显着差异。对 TCGA 的 RNA-seq 数据分析证实了肺癌切除患者中 IL-8 和 CXCR1 高表达与 OS 较差之间的相关性。据我们所知，这项研究是第一个证明负面预后影响的荟萃分析肺癌中 IL-8 水平较高，尤其是接受化疗和/或免疫治疗的患者。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

High interleukin-8 (IL-8) levels have been linked to poor prognosis in lung cancer, but conclusive data are lacking.A comprehensive search was conducted on April 1st, 2023, from electronic databases, focusing on studies with IL-8 expression evaluations and the availability of hazard ratio (HR) and 95% confidence intervals (CI) for overall survival (OS), progression-free survival (PFS) and disease-free survival (DFS) or adequate data for their estimation. Then, we examined IL-8 and CXCR1 RNA-seq data from The Cancer Genome Atlas (TCGA) dataset, and we correlated these data with OS.Among 2655 produced records, 10 manuscripts involving both non-small cell lung cancer and small cell lung cancer, were included in the analysis. Two manuscripts and one study included two and three different cohorts, respectively, for a total of 14 cohorts of patients. Overall, 4 cohorts evaluated IL-8 levels in patients treated with chemotherapy, 3 cohorts immunotherapy, 2 cohorts surgical patients and 4 cohorts other treatments; 1 cohort was removed, as the type of treatments was lacking. The 12 cohorts included in the OS analysis revealed that patients with high IL-8 levels have a lower OS probability, as compared to patients with low IL-8 levels (HR=1.75, 95 % CI 1.36-2.26). No significant difference between patients with high and low IL-8 levels was observed in the 8 cohorts available for PFS analysis. Sensitivity analysis according to treatment revealed significant PFS and OS differences for patients treated with chemotherapy or immunotherapy. Analysis of RNA-seq data from TCGA, confirmed the correlation between high IL-8 and CXCR1 expression and worse OS in patients with resected lung cancer.To the best of our knowledge, this study represents the first meta-analysis demonstrating a negative prognostic impact of high IL-8 level in lung cancer, particularly in patients treated with chemotherapy and/or immunotherapy.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.