Shridhar 等人的这项研究。 2016 年通过单核苷酸多态性 (SNP) 分析回顾了口腔潜在恶性疾病 (OPMD) 的遗传易感性。通过检查 2000 年至 2016 年间进行的 47 项研究的数据，该研究强调了与致癌物代谢、DNA 修复、细胞周期控制和免疫炎症反应有关的遗传标记。尽管提供了见解，但对小样本量的过度依赖限制了研究结果的统计功效和普遍性。未来的研究应侧重于更大、更多样化的人群和先进的基因分型技术，以加强对重要遗传变异的检测。整合多组学数据并进行纵向研究将进一步阐明 OPMD 及其进展为口腔癌的分子机制。合作努力对于验证这些发现并开发用于早期检测和预防的生物标志物至关重要。版权所有 © 2024 Elsevier Ltd。保留所有权利。

This study by Shridhar et al. 2016 reviews the genetic susceptibility to oral potentially malignant disorders (OPMD) through the analysis of single nucleotide polymorphisms (SNPs). By examining data from 47 studies conducted between 2000 and 2016, the research highlights genetic markers involved in carcinogen metabolism, DNA repair, cell cycle control, and immune-inflammatory responses. Despite the insights provided, the over-reliance on small sample sizes limits the statistical power and generalizability of the findings. Future research should focus on larger, more diverse populations and advanced genotyping technologies to enhance detection of significant genetic variants. Integrating multi-omics data and conducting longitudinal studies will further elucidate the molecular mechanisms underlying OPMD and its progression to oral cancer. Collaborative efforts are essential to validate these findings and develop biomarkers for early detection and prevention.Copyright © 2024 Elsevier Ltd. All rights reserved.