血液中激活和失活蛋白酶的途径中断可能导致血栓形成和出血问题。亮氨酸氨肽酶 (LAP) 是调节蛋白质和肽活性所必需的外肽酶，被认为是肝脏疾病的临床生物标志物。然而，血清 LAP 活性与出血或血栓形成风险之间的关系，以及控制 LAP 水平的特定组织或器官的识别尚不清楚。我们进行了一项回顾性研究，评估 149,360 名患者的血清 LAP 活性患有 47 种不同疾病和 9,449 名健康人。使用 SPSS V2.6、RStudio V.1.3.1073 和 Python 3.8 中的库进行分析。我们的研究表明，所研究的 47 种疾病中有 21 种显示出中位血清 LAP 活性增加，而 26 种疾病则与活性显着降低相关。尤其是与血栓形成有关的。此外，与对照组相比，大多数疾病的出血和血栓形成风险增加，这表现为 Q25 较高和 Q75 LAP 活性较低。 ROC 分析证实了 LAP 活性作为肝性脑病、肝癌、胰腺炎和胰腺癌等特定疾病生物标志物的有效性。通过主成分分析，将具有相似出血或血栓倾向的疾病分类为簇。这项研究强调了肝脏和胰腺对 LAP 水平的调节影响。血清 LAP 浓度与出血或血栓形成风险之间已建立的联系为各种医疗状况的诊断和预防方法的开发铺平了道路。Thieme。版权所有。

Disruptions in the pathways for activating and deactivating proteases in the bloodstream can lead to thrombosis and bleeding issues. Leucine aminopeptidases (LAPs), which are exopeptidases essential for regulating protein and peptide activities, are recognized as clinical biomarkers for liver diseases. However, the relationship between serum LAP activity and the risks of bleeding or thrombosis, as well as the identification of the specific tissues or organs that control LAP levels, is not well understood.We performed a retrospective study to evaluate serum LAP activities in 149,360 patients with 47 different diseases and 9,449 healthy individuals. The analysis was conducted using SPSS V2.6, RStudio V.1.3.1073, and libraries in Python 3.8.Our research revealed that 21 of the 47 diseases studied showed increased median serum LAP activities, while 26 diseases were associated with significantly lower activities, especially those related to thrombosis. Furthermore, most diseases were found to have an increased risk of bleeding and thrombosis, indicated by higher Q25 and lower Q75 LAP activities compared to the control group. ROC analysis confirmed the effectiveness of LAP activities as biomarkers for specific conditions like hepatic encephalopathy, liver cancer, pancreatitis, and pancreatic cancer. Diseases were categorized into clusters with similar bleeding or thrombotic tendencies through principal component analysis.This study highlighted regulatory influence of the liver and pancreas on LAP levels. The established link between serum LAP concentrations and the risk of bleeding or thrombosis paved the way for the development of diagnostic and preventative approaches for various medical conditions.Thieme. All rights reserved.