报告 12 周高强度间歇训练 (HIIT) 计划对前列腺癌主动监测 (AS) 患者心脏代谢生物标志物的影响，该试验来自前列腺癌主动监测运动 (ERASE) 试验。 52 名男性接受 AS 治疗的前列腺癌患者被随机分为运动组（HIIT；n = 26）或常规护理组（UC；n = 26）。 HIIT 干预包括渐进式、有人监督的有氧 HIIT，强度为 85% 至 95% VO2peak，每次 28 至 40 分钟，每周进行 3 次，持续 12 周。在基线和干预后收集血样以分析心脏代谢生物标志物。协方差分析用于检查组间平均差异。血液数据从干预后的 49/52 (94%) 参与者获得。参与者年龄为 63.4±7.1 岁，40% 肥胖。 HIIT 组参加了 96% 的计划锻炼课程。干预后没有观察到组间体重的显着变化。与UC相比，HIIT显着改善总胆固醇（-0.40mmol/L；95%置信区间[CI]，-0.70至-0.10；p =0.011）、非高密度脂蛋白-c（-0.35mmol/L；95%置信区间[CI]，-0.70至-0.10；p = 0.011）。 95% CI，-0.60 至 -0.11；p = 0.006)，胰岛素 (-13.6 pmol/L；95% CI，-25.3 至 -1.8；p = 0.025)，胰岛素样生长因子 (IGF)-1 (- 15.0ng/mL；95% CI，-29.9 至 -0.1；p = 0.048)，IGF 结合蛋白 (IGFBP)-3 (152.3ng/mL；95% CI，12.6 至 292.1；p = 0.033)。空腹血糖、HbA1c、其他脂质标志物、IGFBP-1、脂联素和瘦素没有观察到显着差异。ERASE 试验表明，为期 12 周的有氧 HIIT 计划改善了 AS 前列腺癌患者的几种心脏代谢生物标志物，这可能有助于对心血管健康有益，并可能影响前列腺癌进展的信号通路。需要进一步研究来确认运动对前列腺癌男性 AS 心脏代谢标志物的影响，并确定这些影响是否与改善长期临床结果相关。© 2024。作者，获得 Springer Nature 独家许可有限的。

To report the effects of a 12-week high-intensity interval training (HIIT) program on cardiometabolic biomarkers in patients with prostate cancer on active surveillance (AS) from the Exercise During Active Surveillance for Prostate Cancer (ERASE) Trial.Fifty-two men with prostate cancer on AS were randomized to either an exercise (HIIT; n = 26) or usual care (UC; n = 26) group. The HIIT intervention consisted of progressive, supervised, aerobic HIIT at an intensity of 85 to 95% VO2peak for 28 to 40 min per session performed three times/week for 12 weeks. Blood samples were collected at baseline and postintervention to analyze cardiometabolic biomarkers. Analysis of covariance was used to examine between-group mean differences.Blood data were obtained from 49/52 (94%) participants at postintervention. Participants were aged 63.4 ± 7.1 years and 40% were obese. The HIIT group attended 96% of the planned exercise sessions. No significant between-group changes in weight were observed after the intervention. Compared to UC, HIIT significantly improved total cholesterol (-0.40 mmol/L; 95% confidence interval[CI], -0.70 to -0.10; p = 0.011), non-high-density lipoprotein-c (-0.35 mmol/L; 95% CI, -0.60 to -0.11; p = 0.006), insulin (-13.6 pmol/L; 95% CI, -25.3 to -1.8; p = 0.025), insulin-like growth factor (IGF)-1 (-15.0 ng/mL; 95% CI, -29.9 to -0.1; p = 0.048), and IGF binding protein (IGFBP)-3 (152.3 ng/mL; 95% CI, 12.6 to 292.1; p = 0.033). No significant differences were observed for fasting glucose, HbA1c, other lipid markers, IGFBP-1, adiponectin, and leptin.The ERASE Trial showed that a 12-week aerobic HIIT program improved several cardiometabolic biomarkers in patients with prostate cancer on AS that may contribute to cardiovascular health benefits and potentially influence signaling pathways in the progression of prostate cancer. Further research is needed to confirm the effects of exercise on cardiometabolic markers in men with prostate cancer on AS and determine if these effects are associated with improved long-term clinical outcomes.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.