p53 处于肿瘤免疫的十字路口。
p53 at the crossroads of tumor immunity.
发表日期：2024 Jul 15
作者：
Gizem Efe, Anil K Rustgi, Carol Prives
来源：
Nature Cancer
摘要：
p53 肿瘤抑制蛋白具有多种细胞固有功能和影响不同细胞类型和组织的后果。最近的研究开始揭示野生型和突变型 p53 如何以不同的方式发挥作用来调节肿瘤免疫。这在肿瘤免疫监视和逃避之间建立了不平衡。利用这一新兴知识进行转化的能力可能会影响未来的免疫疗法和靶向治疗，特别是在组合治疗中。© 2024。Springer Nature America, Inc.
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell types and tissues. Recent studies are beginning to unravel how wild-type and mutant p53 work in distinct ways to modulate tumor immunity. This sets up a disequilibrium between tumor immunosurveillance and escape therefrom. The ability to exploit this emerging knowledge for translational approaches may shape immunotherapy and targeted therapeutics in the future, especially in combinatorial settings.© 2024. Springer Nature America, Inc.