乳酰化是一种新兴的翻译后修饰，在消化系统肿瘤的发生和进展中发挥着关键作用。这项研究对消化系统肿瘤中的乳酰化进行了全面综述，强调了其在肿瘤发生和进展中的关键作用。通过关注代谢重编程、肿瘤微环境的调节以及调节肿瘤进展的分子机制，突出了以乳酰化为目标的治疗策略的潜力。研究表明，乳酰化通过影响组蛋白和非组蛋白的翻译后状态，参与基因表达调控和细胞信号传导，从而影响肿瘤细胞的代谢途径和免疫逃避机制。此外，本研究评估了乳酰化作为治疗靶点的可行性，为胃肠癌的临床治疗提供了见解。未来的研究应集中于阐明乳酰化机制，开发有效的乳酰化抑制剂，并在临床试验中验证其治疗效果，这可能会改变当前的癌症治疗和免疫治疗方法。总之，这篇综述通过对其分子机制和临床意义的详细分析，强调了乳酰化在肿瘤发生和进展中的关键作用。© 2024。作者。

Lactylation, an emerging post-translational modification, plays a pivotal role in the initiation and progression of digestive system tumors. This study presents a comprehensive review of lactylation in digestive system tumors, underscoring its critical involvement in tumor development and progression. By focusing on metabolic reprogramming, modulation of the tumor microenvironment, and the molecular mechanisms regulating tumor progression, the potential of targeting lactylation as a therapeutic strategy is highlighted. The research reveals that lactylation participates in gene expression regulation and cell signaling by affecting the post-translational states of histones and non-histone proteins, thereby influencing metabolic pathways and immune evasion mechanisms in tumor cells. Furthermore, this study assesses the feasibility of lactylation as a therapeutic target, providing insights for clinical treatment of gastrointestinal cancers. Future research should concentrate on elucidating the mechanisms of lactylation, developing efficient lactylation inhibitors, and validating their therapeutic efficacy in clinical trials, which could transform current cancer treatment and immunotherapy approaches. In summary, this review emphasizes the crucial role of lactylation in tumorigenesis and progression through a detailed analysis of its molecular mechanisms and clinical significance.© 2024. The Author(s).