晚期实体瘤患者的感染诊断可能具有挑战性，因为由于副肿瘤状况，体征和症状可能重叠。对现有感染的延迟诊断可能会导致更严重的病情和更高的死亡率。降钙素原 (PCT) 已用于支持细菌感染和败血症的诊断。不幸的是，即使没有感染，PCT 也会增加恶性肿瘤的发生率。我们调查了 PCT 对发热的晚期实体瘤患者诊断败血症的诊断准确性。对 2016 年 6 月至 2018 年 4 月期间入住印度尼西亚 Cipto Mangunkusumo 医院的发热晚期实体瘤患者进行了一项横断面研究。使用 2001 SCCM/ESICM/ACCP/ATS/SIS 国际败血症定义会议标准进行定义。 PCT的诊断准确性使用受试者工作特征（ROC）曲线来确定。本研究共有194名受试者。 60.3%为女性，平均年龄49.47±12.87岁。 143 名晚期实体瘤患者（73.7%）。在后一组中，39 名患者 (27%) 患有脓毒症。 ROC曲线显示，发热晚期实体瘤患者脓毒症的PCT水平在曲线下面积（AUC）0.853（95%CI 0.785 - 0.921）。 PCT对发热晚期实体瘤患者脓毒症诊断的临界值为2.87 ng/mL，敏感性为79.5%，特异性为79.8%。PCT对发热晚期实体瘤患者具有良好的诊断准确性。归类为脓毒症，但与非癌症患者相比，应使用更高的截止值。

Diagnosis of infection in advanced solid tumor patients can be challenging since signs and symptoms might be overlapping due to paraneoplastic condition. Delay diagnosis of existing infection can lead to more severe conditions and increased mortality. Procalcitonin (PCT) has been used to support the diagnosis of bacterial infection and sepsis. Unfortunately, PCT also increases in malignancy even without an infection. We investigated the diagnostic accuracy of PCT in advanced solid tumor patients with fever to diagnose sepsis.A cross-sectional study was conducted in solid advanced tumor patients with fever patients who were admitted to Cipto Mangunkusumo Hospitals, Indonesia between June 2016 and April 2018. Sepsis was defined using 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference criteria. The diagnostic accuracy of PCT was determined using the receiver operating characteristic (ROC) curve.A total of 194 subjects were enrolled in this study. 60.3% were female with a mean age of 49.47±12.87 years old. 143 patients (73.7%) with advanced solid tumors. Among this latter group, 39 patients (27%) were sepsis. The ROC curve showed that the levels of PCT for sepsis in advanced solid tumor patients with fever were in the area under the curve (AUC) 0.853 (95%CI 0.785 - 0.921). The Cut-off of PCT in advanced solid tumor patients with fever to classify as sepsis was 2.87 ng/mL, with a sensitivity of 79.5%, and a specificity of 79.8%.PCT has good diagnosis accuracy in advanced solid tumor patients with fever to classify as sepsis, however a higher cut-off compared to non-cancerous patients should be used.