ROS诱导的炎症性疾病和癌症中的细胞焦亡
ROS induced pyroptosis in inflammatory disease and cancer
DOI 原文链接
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影响因子:5.9
分区:医学2区 / 免疫学2区
发表日期:2024
作者:
Jingsong Wang, Ziyong Wu, Min Zhu, Yang Zhao, Jingwen Xie
DOI:
10.3389/fimmu.2024.1378990
摘要
焦亡（pyroptosis）是一种依赖于caspase-1的细胞死亡形式，也被称为炎症依赖性死亡，在中风、心脏疾病或肿瘤等疾病中发挥着关键作用。自其被阐明以来，焦亡引起了各界的广泛关注。活性氧（Reactive Oxygen Species, ROS）能够调控多种细胞信号通路。通过对ROS与焦亡的进一步研究，发现ROS水平在焦亡的发生中起着关键作用，两者之间建立了密切关系。本文主要聚焦于ROS与肿瘤及炎症性疾病中焦亡的分子机制，探讨可能作为药物靶点的关键蛋白，连接ROS与焦亡，以及新兴的靶向焦亡的研究领域。此外，未来潜在的影响ROS调控的细胞焦亡的化合物和蛋白质的研究也被展望，旨在为抗肿瘤和抗炎药的开发提供新的思路。
Abstract
Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.