ROS诱导的炎性疾病和癌症的凋亡
ROS induced pyroptosis in inflammatory disease and cancer
影响因子:5.90000
分区:医学2区 / 免疫学2区
发表日期:2024
作者:
Jingsong Wang, Ziyong Wu, Min Zhu, Yang Zhao, Jingwen Xie
摘要
凋亡是caspase-1依赖性细胞死亡的一种形式，也称为炎症依赖性死亡，在中风，心脏病或肿瘤等疾病中起着至关重要的作用。自从阐明以来，凋亡引起了各个部门的广泛关注。活性氧（ROS）可以调节许多细胞信号通路。通过对ROS和凋亡的进一步研究，ROS的水平揭示出对发生pyroptosis的发生至关重要，从而建立了两者之间的密切关系。这篇综述主要集中于肿瘤和炎症性疾病中ROS和凋亡的分子机制，探索可能用作关键的蛋白质，这些蛋白可能是将ROS和Pyroptosis和靶向凋亡的新兴领域联系起来的药物。此外，预计会影响ROS调节细胞凋亡的化合物和蛋白质的潜在发展，旨在为抗肿瘤和抗炎药的发展提供见解。
Abstract
Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.