细胞焦亡是 caspase-1 依赖性细胞死亡的一种形式，也称为炎症依赖性死亡，在中风、心脏病或肿瘤等疾病中发挥着至关重要的作用。自其被阐明以来，细胞焦亡引起了各界的广泛关注。活性氧（ROS）可以调节许多细胞信号通路。通过对ROS和焦亡的进一步研究，发现ROS水平对于焦亡的发生至关重要，建立了两者之间的密切关系。本综述主要关注肿瘤和炎症性疾病中ROS和焦亡的分子机制，探索可能作为连接ROS和焦亡的药物靶点的关键蛋白以及针对焦亡的新兴领域。此外，预计未来可能开发影响ROS调节细胞焦亡的化合物和蛋白质，旨在为抗肿瘤和抗炎药物的开发提供见解。版权所有©2024 Wang、Wu、Zhu、Zhao和Xie。

Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.Copyright © 2024 Wang, Wu, Zhu, Zhao and Xie.