聚乙二醇化 (PEG)-天冬酰胺酶引起的急性胰腺炎与严重高甘油三酯血症相关。
Acute Pancreatitis Caused by Pegylated (PEG)-Asparaginase Associated With Severe Hypertriglyceridemia.
发表日期:2024 Jun
作者:
Sumina Rai, Prabhat Sharma, Anamika Nepal, Sajana Poudel, Yannis Guerra
来源:
Cell Death & Disease
摘要:
聚乙二醇化 (PEG)-天冬酰胺酶用于 B 细胞急性淋巴细胞白血病 (B-ALL) 治疗的诱导期和强化期。它的作用是耗尽天冬酰胺的外部来源,导致淋巴母细胞死亡。它有多种副作用,包括胰腺炎和高甘油三酯血症;然而,两者同时发生的情况并不常见。我们介绍了一名患有 B-ALL 的 18 岁男性病例,他在接受 PEG-天冬酰胺酶治疗后出现急性上腹疼痛,放射至背部,并且出现非血性、非胆汁性呕吐。他被诊断患有急性间质性胰腺炎和严重的高甘油三酯血症。胰腺炎采用保守治疗,而高甘油三酯血症则采用胰岛素输注治疗。胰腺毒性和高甘油三酯血症可能需要停止使用 PEG-天冬酰胺酶,从而限制了治疗选择并可能增加复发风险。因此,需要进一步研究以确定导致高甘油三酯血症和胰腺炎的因素,帮助临床医生进行监测和预防。版权所有 © 2024,Rai 等人。
Pegylated (PEG)-asparaginase is used during the induction and intensification phases of treatment for B-cell acute lymphoblastic leukemia (B-ALL). It works by depleting the external sources of asparagine, causing the death of lymphoblasts. It has several adverse effects, including pancreatitis and hypertriglyceridemia; however, the simultaneous occurrence of both is uncommon. We present the case of an 18-year-old man with B-ALL who developed acute epigastric pain radiating to the back and non-bloody, non-bilious emesis following treatment with PEG-asparaginase. He was diagnosed with acute interstitial pancreatitis and severe hypertriglyceridemia. Conservative management was used for the pancreatitis, while hypertriglyceridemia was treated with an insulin infusion. Pancreatic toxicity and hypertriglyceridemia can necessitate the discontinuation of PEG-asparaginase, limiting treatment options and potentially increasing the risk of relapse. Therefore, further studies are needed to identify the factors contributing to hypertriglyceridemia and pancreatitis, aiding clinicians in monitoring and prevention.Copyright © 2024, Rai et al.