预防疾病和维护老年人健康是人口老龄化的重要目标，其中肥胖和免疫功能恢复至关重要。肥胖，特别是以腹部器官周围脂肪过多堆积为特征的内脏肥胖，与糖尿病、高血压、心血管疾病和免疫功能障碍等慢性疾病有关。在全球范围内，肥胖被认为是一种疾病，引发了对其治疗的重大研究兴趣。因此，有必要探索潜在的治疗和预防策略来解决肥胖和衰老带来的免疫功能下降问题。黄粉虫幼虫 (TML)，俗称“黄粉虫”，富含不饱和脂肪酸，包括油酸和亚油酸，以及必需氨基酸，如异亮氨酸和酪氨酸。在这项研究中，我们旨在研究食用TML油和黄粉虫发酵提取物（MWF-1）对老年肥胖小鼠的肥胖和免疫变化的影响。我们的数据显示，23 周龄的 C57BL/6 小鼠喂食加工 TML 产品 6 周后，体内脂肪减少。此外，通过 TML 油处理，血清甘油三酯的特有高水平得以降低。免疫反应结果证实，通过 MWF-1 治疗，B 细胞有所增加，同时细胞因子水平（干扰素-γ、肿瘤坏死因子-α、白细胞介素-2 和 -6）恢复到与年轻小鼠相似的水平。这些结果表明 TML 油和 MWF-1 是解决肥胖和恢复免疫功能的有前景的膳食补充剂。© 2024 作者。由 Informa UK Limited 出版，以 Taylor 名义进行交易

Preventing disease and maintaining the health of the elderly are crucial goals for an aging population, with obesity and immune function restoration being of paramount importance. Obesity, particularly visceral obesity characterized by excessive fat accumulation around the abdominal organs, is linked to chronic conditions such as diabetes, hypertension, cardiovascular diseases, and immune dysfunction. Globally, obesity is considered a disease, prompting significant research interest in its treatment. Therefore, it is essential to explore potential therapeutic and preventive strategies to address obesity and the decline in immune function brought about by aging. Tenebrio molitor larvae (TML), commonly known as 'mealworms,' are rich in unsaturated fatty acids, including oleic and linoleic acids, and essential amino acids, such as isoleucine and tyrosine. In this study, we aimed to investigate the effects of the consumption of TML oil and mealworm fermented extract (MWF-1) on obesity and immunological changes in aged obese mice. Our data showed reduced body fat in 23-week-old C57BL/6 mice fed processed TML products for 6 weeks. Additionally, the characteristically high levels of serum triglycerides decreased by treating with TML oil. The immune responsiveness results confirmed an increase in B cells by treating with MWF-1, while cytokine levels (interferon-gamma, tumor necrosis factor-alpha, interleukin-2, and -6) were restored to levels similar to young mice. These results suggest that TML oil and MWF-1 are promising dietary supplements for addressing obesity and restoring immune function.© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.