多形性胶质母细胞瘤 (GBM) 是一种高度侵袭性且预后具有挑战性的脑癌，由于血脑屏障 (BBB) 的存在以及在深部 GBM 病变中维持有效药物积累的困难，给当前的治疗带来了重大障碍。提出了一种带有 angiopep-2 修饰的巨噬细胞膜的仿生纳米平台，负载有吲哚菁绿（ICG）模板的 SN38（AM-NP）自组装，通过特定的配体-受体相互作用促进主动肿瘤靶向和有效的血脑屏障渗透。在肿瘤部位积累后，这些纳米颗粒达到了高药物浓度。随后激光照射和化疗剂 SN38 释放的结合诱导了协同化学光热疗法。与缺乏细胞膜封装的裸纳米颗粒（NP）相比，AM-NPs显着抑制肿瘤生长，显着提高存活率，并表现出优异的生物相容性和最小的副作用。这种近红外激活的仿生伪装巨噬细胞膜纳米颗粒增强了药物递送靶向能力通过巨噬细胞膜和特定配体的修饰。同时实现了化学光热协同治疗，提高了治疗效果。与传统的治疗方式相比，它提供了一种精确、高效和协同的方法，可能有助于胶质母细胞瘤治疗的进步。© 2024 Li et al.

Glioblastoma multiforme (GBM), a highly invasive and prognostically challenging brain cancer, poses a significant hurdle for current treatments due to the existence of the blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions.We present a biomimetic nanoplatform with angiopep-2-modified macrophage membrane, loaded with indocyanine green (ICG) templated self-assembly of SN38 (AM-NP), facilitating active tumor targeting and effective blood-brain barrier penetration through specific ligand-receptor interaction.Upon accumulation at tumor sites, these nanoparticles achieved high drug concentrations. Subsequent combination of laser irradiation and release of chemotherapy agent SN38 induced a synergistic chemo-photothermal therapy. Compared to bare nanoparticles (NPs) lacking cell membrane encapsulation, AM-NPs significantly suppressed tumor growth, markedly enhanced survival rates, and exhibited excellent biocompatibility with minimal side effects.This NIR-activatable biomimetic camouflaging macrophage membrane-based nanoparticles enhanced drug delivery targeting ability through modifications of macrophage membranes and specific ligands. It simultaneously achieved synergistic chemo-photothermal therapy, enhancing treatment effectiveness. Compared to traditional treatment modalities, it provided a precise, efficient, and synergistic method that might have contributed to advancements in glioblastoma therapy.© 2024 Li et al.