急性主动脉综合征（AAS）是一种危及生命的疾病，其主动脉壁完整性发生断裂。 γ-谷氨酰转移酶与淋巴细胞比率（GLR）被认为是肝硬化、纤维化和肝细胞癌的危险因素。但目前尚无GLR和AAS的临床报道。我们试图确定中国南方潮汕地区患者的 GLR 水平是否与 AAS 相关。本研究共招募了 2,384 名患者，根据 CT 血管造影结果分为 AAS 组和无 AAS 组。胸腹主动脉。进行单变量和多变量逻辑回归以确定 AAS 发生的危险因素。应用 ROC 评估 D-二聚体、GLR 单独或组合对 AAS 诊断的价值。并进行1：1倾向评分匹配分析。多因素logistic回归分析显示，倾向评分匹配前队列中男性、年龄、高血压、糖尿病、肌酐、D-二聚体、GLR是AAS患者的独立危险因素。倾向评分匹配后显示D-二聚体、GLR[OR 3.558(1.891,6.697)； p<<0.001]是AAS患者的独立危险因素。在倾向评分匹配之前，GLR 的曲线下面积 (AUC) 为 0.822，D-二聚体的曲线下面积 (AUC) 为 0.767。调整两个临床背景后，GLR 的 AUC 为 0.773，D-二聚体的 AUC 为 0.631。在倾向评分匹配前后队列中GLR表现出较高的特异性（80.5%和77.1%），D-二聚体表现出较高的敏感性（84.7%和73.6%）。GLR和D-二聚体是急性主动脉综合征的独立危险因素。 D-二聚体与 GLR 联合对于诊断急性主动脉综合征比单一指标更有价值。© 2024 Li, Xu, Chen, Lai, Chen, Shu and Tan.

Acute aortic syndrome (AAS) is a life-threatening condition in which there is a fracture in the integrity of the aortic wall. gamma-glutamyl transferase to lymphocyte ratio (GLR) is recognized as a risk factor for liver cirrhosis, fibrosis, and hepatocellular carcinoma. However, there are no clinical reports of GLR and AAS. We attempted to determine whether GLR level is associated with AAS in patients from the Chaoshan region of southern China.A total of 2,384 patients were recruited in this study and were divided into AAS and no-AAS groups according to the results of CT angiography of the thoracoabdominal aorta. Univariate and multivariate logistic regression was performed to identify risk factors for the occurrence of AAS. ROC was applied to assess the value of D-Dimer, GLR alone, or in combination for the diagnosis of AAS. And a 1:1 propensity score-matched analysis was performed.Multivariate logistics regression analysis indicated that male, age, hypertension, diabetes, creatinine, D-dimer, and GLR were independent risk factors of AAS patients in the before propensity score-matching cohort. After propensity score-matching, it showed that D-dimer, GLR [OR 3.558(1.891, 6.697); p < 0.001] were independent risk factors of AAS patients. Before propensity score-matching, the area under the curve (AUC) was 0.822 of GLR and 0.767 of D-dimer. When both clinical backgrounds were adjusted, the AUC was 0.773 of GLR and 0.631 of D-dimer. GLR showed high specificity (80.5% and 77.1%), and D-dimer showed high sensitivity (84.7% and 73.6%) in the before and after propensity score-matching cohort.GLR and D-dimer were independent risk factors of acute aortic syndrome. D-dimer in combination with GLR is more valuable than a single indicator for diagnosing acute aortic syndrome.© 2024 Li, Xu, Chen, Lai, Chen, Shu and Tan.