作为一种日益知名的香豆素衍生物，瑞香素（7,8-二羟基香豆素）已被证明具有多种药理活性，包括抗炎、抗癌、抗自身免疫性疾病、抗菌、器官保护和神经保护特性。鉴于其在临床上的治疗潜力，人们进行了各种研究来探索瑞香素的作用机制和合成方法。尽管有这些初步见解，瑞香素药理活性的确切机制仍然很大程度上未知。为了弥补这一知识空白，我们从信号通路、NOD样受体蛋白3（NLRP3）炎症小体和炎症因子的角度探讨了分子效应；并尝试找出如何利用这些机制来制定新的联合治疗策略。版权所有 © 2024 Wei、Wei、Su 和 Gau。

As an increasingly well-known derivative of coumarin, daphnetin (7,8-dithydroxycoumarin) has demonstrated various pharmacological activities, including anti-inflammation, anti-cancer, anti-autoimmune diseases, antibacterial, organ protection, and neuroprotection properties. Various studies have been conducted to explore the action mechanisms and synthetic methods of daphnetin, given its therapeutic potential in clinical. Despite these initial insights, the precise mechanisms underlying the pharmacological activities of daphnetin remain largely unknown. In order to address this knowledge gap, we explore the molecular effects from the perspectives of signaling pathways, NOD-like receptor protein 3 (NLRP3) inflammasome and inflammatory factors; and try to find out how these mechanisms can be utilized to inform new combined therapeutic strategies.Copyright © 2024 Wei, Wei, Su and Gao.