本综述强调了纳米药物递送系统（NDDS）在增强肿瘤免疫治疗功效方面的重要作用。重点关注 NDDS 与免疫调节策略的整合，探讨其对肿瘤微环境和免疫反应动态的变革性影响。主要进展包括通过 NDDS 优化药物输送、免疫检查点阻断等靶向机制以及调节免疫抑制肿瘤环境。尽管取得了进展，但临床疗效有限和制造工艺复杂等挑战仍然存在。该评论强调需要进一步研究来优化这些系统，通过提高递送效率、降低毒性和克服免疫抵抗力，可能彻底改变癌症治疗。

This review highlights the significant role of nanodrug delivery systems (NDDS) in enhancing the efficacy of tumor immunotherapy. Focusing on the integration of NDDS with immune regulation strategies, it explores their transformative impacts on the tumor microenvironment and immune response dynamics. Key advancements include the optimization of drug delivery through NDDS, targeting mechanisms like immune checkpoint blockade and modulating the immunosuppressive tumor environment. Despite the progress, challenges such as limited clinical efficacy and complex manufacturing processes persist. The review emphasizes the need for further research to optimize these systems, potentially revolutionizing cancer treatment by improving delivery efficiency, reducing toxicity and overcoming immune resistance.