通过金角径向采样动态增强磁共振成像预测胃癌患者腹膜癌细胞的预测
Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging
影响因子:4.90000
分区:医学2区 / 生化与分子生物学2区 生物工程与应用微生物2区 医学：研究与实验2区
发表日期:2024 Jun 05
作者:
Xueqing Yin, Xinzhong Ruan, Yongmeng Zhu, Yongfang Yin, Rui Huang, Chao Liang
摘要
无腹膜癌细胞会对胃癌的疾病进展和患者结局产生负面影响。这项研究旨在调查使用金角径向采样动态对比增强的磁共振成像（GRASP DCE-MRI）预测胃癌患者中腹膜无癌细胞的存在。所有招募的患者均将其连续分为分析和验证组。在接受手术的胃癌患者中，进行了术前磁共振成像（MRI）扫描和灌注，并收集腹膜灌洗样本进行检查。根据腹膜灌洗细胞学（PLC）的结果，将患者分为阴性和阳性灌洗液组。收集的数据包括临床和MR信息。构建了一个名义图预测模型，以预测腹膜灌洗液的正率，并根据验证组的数据验证了该模型的有效性。在GRASP DCE-MR预测的PLC阳性病例的比例之间没有统计差异。 MR肿瘤期，肿瘤厚度和灌注参数TOFTS-KITTY模型体积转移常数（KTRAN）是腹膜正灌洗液的独立预测指标。列诺图模型的特征是建模和验证组的一致性指数（C-指数）分别为0.785和0.742。GRASPDCE-MR可以有效地预测胃癌患者中的腹膜无腹部癌细胞。使用这些预测因素构建的命名图模型可能有助于临床医生更好地预测胃癌患者存在于腹膜无腹膜细胞的风险。
Abstract
Peritoneal free cancer cells can negatively impact disease progression and patient outcomes in gastric cancer. This study aimed to investigate the feasibility of using golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging (GRASP DCE-MRI) to predict the presence of peritoneal free cancer cells in gastric cancer patients.All enrolled patients were consecutively divided into analysis and validation groups. Preoperative magnetic resonance imaging (MRI) scans and perfusion were performed in patients with gastric cancer undergoing surgery, and peritoneal lavage specimens were collected for examination. Based on the peritoneal lavage cytology (PLC) results, patients were divided into negative and positive lavage fluid groups. The data collected included clinical and MR information. A nomogram prediction model was constructed to predict the positive rate of peritoneal lavage fluid, and the validity of the model was verified based on data from the verification group.There was no statistical difference between the proportion of PLC-positive cases predicted by GRASP DCE-MR and the actual PLC test. MR tumor stage, tumor thickness, and perfusion parameter Tofts-Ketty model volume transfer constant (Ktrans) were independent predictors of positive peritoneal lavage fluid. The nomogram model featured a concordance index (C-index) of 0.785 and 0.742 for the modeling and validation groups, respectively.GRASP DCE-MR could effectively predict peritoneal free cancer cells in gastric cancer patients. The nomogram model constructed using these predictors may help clinicians to better predict the risk of peritoneal free cancer cells being present in gastric cancer patients.