腹膜癌病患者经常遭受骨骼肌质量损失并需要广泛的手术。多模式预康复可以改善身体状况，但其对这些特定患者的益处仍然未知。本研究旨在评估预康复对功能步行能力和骨骼肌质量的影响，及其与术后并发症的关系。对接受家庭三模式预康复计划的腹膜癌患者进行了一项前瞻性研究。功能性步行能力通过 6 分钟步行测试 (T6MWT) 以及通过生物电阻抗分析估算的四肢骨骼肌指数 (ASMI) 进行评估。在第一次医疗预约和手术前一天收集数据。根据 Clavien-Dindo 分类记录术后 90 天的发病率。分析中共有 62 名患者。女性多见（77.4%），卵巢来源的腹膜转移占48.4%。 30 名患者 (57.7%) 出现 Clavien II-V 级。预康复后，与基线数据相比，功能性步行能力提高了 42.2 m (39.62-44.72 m) (p < 0.001)，但 ASMI 没有观察到改善 (p = 0.301)。预康复后能够行走至少 360 m 的患者 Clavien-Dindo II-V 术后并发症较少 (p = 0.016)。在多变量分析中，T6MWT 小于 360 m 被确定为独立危险因素（OR 3.99；1.01-15.79 p = 0.048）。这种家庭三模式预康复计划改善了腹膜转移患者的功能性步行能力，但没有改善 ASMI 评分手术前。发现小于 360 m 的 T6MWT 是术后并发症的危险因素。© 2024。外科肿瘤学会。

Patients with peritoneal carcinomatosis often suffer from loss of skeletal muscle mass and require extensive surgery. Multimodal prehabilitation may improve physical status but its benefits for these specific patients remain unknown. This study aimed to evaluate the effect of prehabilitation on functional walking capacity and skeletal muscle mass, as well as its association with postoperative complications.A prospective study of patients with peritoneal carcinomatosis following a home-based trimodal prehabilitation program was carried out. Functional walking capacity was assessed with the 6-min walk test (T6MWT), and by the appendicular skeletal muscle index (ASMI) estimated by bioelectrical impedance analysis. Data were collected at the first medical appointment and on the day before surgery. A 90-day postoperative morbidity was registered according to the Clavien-Dindo classification.A total of 62 patients were included in the analysis. Women were more prevalent (77.4%) and peritoneal metastasis from ovarian origin accounted for 48.4%. Clavien II-V grades occurred in 30 (57.7%) patients. After prehabilitation, functional walking capacity improved by 42.2 m (39.62-44.72 m) compared with baseline data (p < 0.001), but no improvement was observed in the ASMI (p = 0.301). Patients able to walk at least 360 m after prehabilitation suffered fewer Clavien-Dindo II-V postoperative complications (p = 0.016). A T6MWT of less than 360 m was identified as an independent risk factor in the multivariable analysis (OR 3.99; 1.01-15.79 p = 0.048).This home-based trimodal prehabilitation program improved functional walking capacity but not ASMI scores in patients with peritoneal metastasis before surgery. A T6MWT of less than 360 m was found to be a risk factor for postoperative complications.© 2024. Society of Surgical Oncology.