癌症是一种致命疾病，在发展中国家死亡率很高。最近的一项临床前研究发现，联合使用乙酰水杨酸（ASA）和抗坏血酸（AS）治疗肝细胞癌（HCC）具有良好的效果，这可能为昂贵的临床化疗药物提供更安全的替代方案；然而，这种组合对其他肿瘤的影响仍有待探索。因此，本研究旨在探讨ASA和AS联合治疗艾利希实体瘤的有效性。将80只雌性瑞士白化小鼠分为八组（10只/组）：四个健康组（健康组、AS组、ASA组、ASA组） ）和四组癌症组（艾氏腹水癌 [EAC]、EAC AS、EAC ASA 和 EAC AS ASA）。 AS 每天腹腔注射（4 g/kg），持续 10 天，而 ASA 则以 60 mg/kg/天口服摄入，持续 10 天。皮下注射1×106个EAC细胞/小鼠一次诱导癌变。肿瘤接种10天后开始治疗癌症。获取血液、肝脏和肿瘤，以及肿瘤重量、体积和血红蛋白、转氨酶、白蛋白、胆红素、尿素、肌酸酐、脂质谱、丙二醛、一氧化氮、谷胱甘肽、过氧化氢酶、总抗氧化能力、乳酸脱氢酶和肌酸激酶进行了估计。还评估了寿命增加的百分比。肿瘤治疗减轻了肿瘤负担。肿瘤尺寸减小，寿命延长，器官（肝、肾和心脏）功能调整，血红蛋白、血脂状况改善，氧化应激减少。将 ASA 与 AS 结合显示出比单独使用 ASA 或单独使用 AS 更有效的抗肿瘤作用。经过更多验证研究，将 ASA 与 AS 结合可能会为癌症治疗带来益处。© 2024。作者。

Cancer is a deadly disease with high mortality rates in developing countries. A recent preclinical study found promising results in treating hepatocellular carcinoma (HCC) by combining acetylsalicylic acid (ASA) and ascorbate (AS), which might offer a safer alternative to expensive clinical chemotherapeutics; however, the impact of this combination on other tumors remains unexplored. Therefore, this study aims to investigate the effectiveness of combining ASA and AS in treating Ehrlich solid tumors.Eighty female Swiss albino mice were divided into eight groups (10 mice/group): four healthy groups (healthy, AS, ASA, and AS+ASA) and four groups with carcinoma (Ehrlich ascites carcinoma [EAC], EAC+AS, EAC+ASA, and EAC+AS+ASA). AS was injected intraperitoneally (4 g/kg) daily for 10 days, whereas ASA was ingested orally at 60 mg/kg/day for 10 days. Carcinoma was induced by subcutaneous injection of 1×106 EAC cells/mouse once. Treatment of carcinoma started after 10 days of tumor inoculation. Blood, livers, and tumors were obtained, and tumor weights, volumes, and levels of hemoglobin, aminotransferases, albumin, bilirubin, urea, creatinine, lipid profile, malondialdehyde, nitric oxide, glutathione, catalase, total antioxidant capacity, lactate dehydrogenase, and creatine kinase were estimated. The percentage increase in lifespan was also assessed.Tumor treatment alleviated tumor burden. Tumor size was reduced, lifespan increased, organs (liver, kidney, and heart) functions adjusted, hemoglobin, lipid profile improved, and oxidative stress decreased. Combining ASA with AS showed more effective antitumor effects than only ASA or AS alone.After more validation research, combining ASA with AS may provide benefit in cancer treatment.© 2024. The Author(s).