事实上，Salvadora persica L.（萨尔瓦多拉斯科）的所有部分都用于传统医学。树枝和叶子用于口腔健康，但对叶子的研究要少得多。这项研究评估了桃叶促进口腔健康的潜力，重点是抗炎和抗增殖作用，并提供了其代谢物的深入表征对热水和甲醇桃叶提取物（1、10 和 100 µg/mL）及其主要成分（5、10 和 50 µM）进行 IL-8 和 TNFα 释放的细胞测定。 LPS 刺激的人中性粒细胞、LPS/IFNγ 刺激的小鼠巨噬细胞中 NO 的释放以及 HNO97 人舌癌细胞的增殖。通过 UHPLC-HRMS 分析进行代谢物分析。主要成分已被分离并在结构上得到阐明。两种提取物在 LPS 刺激的中性粒细胞中均表现出显着的抗炎活性。鉴定出的主要化合物类别是黄酮苷、芥子油苷、苯基糖苷硫酸盐和苄基糖苷硫酸盐以及巨豆豆糖基硫酸盐，后者是首次在桃花中鉴定出。 Glucotropaeolin 强烈抑制 IL-8 和 TNF-α 的释放（50 µM 刺激对照细胞释放量的 13.3±±2.0 和 22.7±±2.6%），而一些类黄酮和 3-(3'-O-sulfo-β- d-吡喃葡萄糖氧基)-7,8-二氢-β-紫罗兰酮是一种新分离的巨豆烷糖基硫酸酯，具有中等活性。异硫氰酸苄酯很可能是在传统应用桃子的过程中由葡糖皮酚形成的，除了强烈抑制 IL-8 和 TNFα 释放外，还表现出相当大的抗增殖活性（HNO97 细胞中的 IC50：10.19±0.72μM）。葡糖皮酚和异硫氰酸苄酯可能与口腔中的细菌有关。桃叶的健康促进作用。新鉴定的巨豆甘糖基硫酸盐的化学和药理学应进一步评估。

Virtually all parts of Salvadora persica L. (Salvadoraceae) are used in traditional medicine. The twigs and leaves are used for oral health, but leaves are far less investigated.This study assesses the oral health-promoting potential of S. persica leaves with emphasis on anti-inflammatory and antiproliferative effects and provides an in depth-characterization of their metabolite profile.Hot-water and methanolic S. persica leaf extracts (1, 10, and 100 µg/mL) and their major constituents (5, 10, and 50 µM), were subjected to cellular assays on IL-8 and TNFα release in LPS-stimulated human neutrophils, NO-release in LPS/IFNγ stimulated mouse macrophages, and proliferation of HNO97 human tongue carcinoma cells. Metabolite profiling was performed by UHPLC-HRMS analysis. Major constituents were isolated and structurally elucidated.Both extracts showed pronounced anti-inflammatory activity in LPS-stimulated neutrophils. Major identified compound classes were flavonoid glycosides, the glucosinolate glucotropaeolin, phenyl- and benzylglycoside sulfates, and megastigmane glycosylsulfates, the latter ones identified for the first time in S. persica. Glucotropaeolin strongly inhibited the release of IL-8 and TNF-α (13.3 ± 2.0 and 22.7 ± 2.6% of the release of stimulated control cells at 50 µM), while some flavonoids and 3-(3'-O-sulfo-β-d-glucopyranosyloxy)-7,8-dihydro-β-ionone, a newly isolated megastigmane glycosylsulfate, were moderately active. Benzylisothiocyanate, which is likely formed from glucotropaeolin during traditional application of S. persica, showed considerable antiproliferative activity (IC50 in HNO97 cells: 10.19 ± 0.72 µM) besides strongly inhibiting IL-8 and TNFα release.Glucotropaeolin and benzylisothiocyanate are likely implicated in the oral health-promoting effects of S. persica leaves. The chemistry and pharmacology of the newly identified megastigmane glycosylsulfates should be further evaluated.