多项证据表明，衰老细胞的年龄依赖性积累会导致慢性组织微炎症，进而导致与年龄相关的病理。一般来说，衰老细胞可以被宿主的先天性和适应性免疫监视系统消除，包括巨噬细胞、NK细胞和T细胞。免疫监视受损会导致衰老细胞积聚并加速衰老过程。最近，衰老细胞（如癌细胞）已被证明表达某些类型的免疫检查点蛋白以及非经典免疫耐受 MHC 变体，从而导致免疫系统逃避监视系统。因此，免疫检查点阻断 (ICB) 可能是增强衰老免疫监视的一种有前途的策略，从而改善一些与年龄相关的疾病和组织功能障碍。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

Several lines of evidence suggest that the age-dependent accumulation of senescent cells leads to chronic tissue microinflammation, which in turn contributes to age-related pathologies. In general, senescent cells can be eliminated by the host's innate and adaptive immune surveillance system, including macrophages, NK cells, and T cells. Impaired immune surveillance leads to the accumulation of senescent cells and accelerates the aging process. Recently, senescent cells, like cancer cells, have been shown to express certain types of immune checkpoint proteins as well as non-classical immune-tolerant MHC variants, leading to immune escape from surveillance systems. Thus, immune checkpoint blockade (ICB) may be a promising strategy to enhance immune surveillance of senescence, leading to the amelioration of some age-related diseases and tissue dysfunction.Copyright © 2024 Elsevier Ltd. All rights reserved.