茶和咖啡是世界上最常饮用的饮料。绿茶尤其含有具有潜在抗癌作用的化合物，但其与卵巢癌术后生存的关系尚不确定。我们利用卵巢癌协会联盟 10 项研究的数据，研究了诊断前饮用茶和咖啡与生存之间的关系。可获得多达 5724 名女性的茶（绿茶、红茶、草本茶）、咖啡和咖啡因摄入量数据。我们使用 Cox 比例风险回归来估计调整后的风险比 (aHR) 和 95% 置信区间 (CI)。与不喝任何绿茶的女性相比，每天喝一杯或多杯与更好的总体生存率 (aHR) 相关= 0.84，95% CI 0.71-1.00，p 趋势 = 0.04）。在使用该信息的五项研究中，发现卵巢癌特异性生存存在类似的关联（aHR = 0.81、0.66-0.99、p-趋势 = 0.045）。由临床或生活方式特征定义的亚组之间没有一致的差异，并且对生活方式其他方面的调整没有明显改变估计值。我们没有发现咖啡、红茶或花草茶或咖啡因摄入量与生存之间存在关联的证据。所观察到的诊断前饮用绿茶的关联性提出了诊断后饮用绿茶可能改善患者预后的可能性。© 2024。作者。

Tea and coffee are the most frequently consumed beverages in the world. Green tea in particular contains compounds with potential anti-cancer effects, but its association with survival after ovarian cancer is uncertain.We investigated the associations between tea and coffee consumption before diagnosis and survival using data from 10 studies in the Ovarian Cancer Association Consortium. Data on tea (green, black, herbal), coffee and caffeine intake were available for up to 5724 women. We used Cox proportional hazards regression to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI).Compared with women who did not drink any green tea, consumption of one or more cups/day was associated with better overall survival (aHR = 0.84, 95% CI 0.71-1.00, p-trend = 0.04). A similar association was seen for ovarian cancer-specific survival in five studies with this information (aHR = 0.81, 0.66-0.99, p-trend = 0.045). There was no consistent variation between subgroups defined by clinical or lifestyle characteristics and adjustment for other aspects of lifestyle did not appreciably alter the estimates. We found no evidence of an association between coffee, black or herbal tea, or caffeine intake and survival.The observed association with green tea consumption before diagnosis raises the possibility that consumption after diagnosis might improve patient outcomes.© 2024. The Author(s).